Methylprednisolone hemisuccinate

Generic Name: Methylprednisolone hemisuccinate

Brand Names: Solu-medrol

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₃₄O_₈

CAS Number: 2921-57-5

Unique Ingredient Identifier: 5GMR90S4KN

Background: A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Associated Conditions: Acute Gouty Arthritis, Ankylosing Spondylitis (AS), Berylliosis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatitis bullous, Dermatomyositis (DM), Edema of the cerebrum, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Leukemias, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Pemphigus, Polymyositis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Refractory Uveitis, Regional Enteritis, Rheumatoid Arthritis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Allergic Reactions, Symptomatic Sarcoidosis

Associated Therapies: Palliative Treatment

Clinical Trials

Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease

Not Applicable

Completed

Conditions: Nonmalignant Neoplasm
Multiple Myeloma and Plasma Cell Neoplasm
Lymphoma
Leukemia
Unspecified Adult Solid Tumor, Protocol Specific
Myelodysplastic Syndromes

First Posted Date: 2007-08-27

Last Posted Date: 2013-03-26

Lead Sponsor: Asan Medical Center

Target Recruit Count: 30

Registration Number: NCT00521430

Locations: 🇰🇷
Asan Medical Center - University of Ulsan College of Medicine, Seoul, Korea, Republic of

Is IFN-beta Treatment in MS Useful After a Washout Period in Patients With Neutralizing Antibodies to Interferon Beta

Phase 4

Completed

Conditions: Relapsing-Remitting Multiple Sclerosis

Interventions: Drug: Interferon-beta-1a
Drug: methylprednisolone

First Posted Date: 2007-06-27

Last Posted Date: 2013-09-16

Lead Sponsor: Biogen

Target Recruit Count: 20

Registration Number: NCT00493116

Locations: 🇳🇿
Research Site, Hamilton, New Zealand
🇦🇺
Coordinating Research Site, NSW, Australia

Investigating if Interferon-Beta Can be Used in Patients With MS After They Have Developed Neutralizing Antibodies

Phase 4

Completed

Conditions: Relapsing-Remitting Multiple Sclerosis

Interventions: Drug: Interferon-beta-1a
Drug: methylprednisolone

First Posted Date: 2007-06-27

Last Posted Date: 2008-01-30

Lead Sponsor: Biogen

Target Recruit Count: 14

Registration Number: NCT00492466

Locations: 🇫🇮
Coordinating Research Site, Turku, Finland

Phase 2 Poor Risk DLBCL of TLI and ATG Followed by Matched Allogeneic HT as Consolidation to Autologous HCT

Phase 2

Terminated

Conditions: Lymphoma, B-cell
Lymphoma, Non-Hodgkin
Diffuse Large B-cell Lymphoma (DLBCL)
Malignant Lymphoma, Non-Hodgkin

Interventions: Procedure: Autologous hematopoietic stem cell transplantation (auto-HSCT)
Procedure: Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Procedure: Total lymphoid irradiation (TLI)
Drug: Rituximab
Drug: Carmustine
Drug: Etoposide
Drug: Filgrastim
Drug: Anti-thymocyte globulin (ATG)
Drug: Cyclosporine
Drug: Mycophenolate mofetil (MMF)
Drug: Cyclophosphamide
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Hydrocortisone
Drug: Methylprednisolone

First Posted Date: 2007-06-04

Last Posted Date: 2018-05-14

Lead Sponsor: Stanford University

Target Recruit Count: 3

Registration Number: NCT00482053

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma

Phase 2

Terminated

Conditions: Lymphoma, Non-Hodgkin

Interventions: Drug: Cyclophosphamide
Drug: BCNU
Drug: Etoposide
Drug: Filgrastim
Drug: Antithymocyte globulin
Drug: Cyclosporine
Drug: Mycophenolate mofetil
Drug: Rituximab
Procedure: Autologous hematopoietic stem cell transplantation (auto-HSCT)
Procedure: Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Procedure: Total lymphoid irradiation
Drug: CD34+ Cells
Drug: Solu-Medrol

First Posted Date: 2007-06-04

Last Posted Date: 2018-02-14

Lead Sponsor: Stanford University

Target Recruit Count: 50

Registration Number: NCT00481832

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Kidney Transplantation

Phase 3

Completed

Conditions: Kidney Transplantation

Interventions: Drug: FK506MR
Drug: Prograf
Drug: Mycophenolate Mofetil
Drug: Methylprednisolone
Drug: Prednisolone

First Posted Date: 2007-06-04

Last Posted Date: 2016-02-24

Lead Sponsor: Astellas Pharma Inc

Target Recruit Count: 240

Registration Number: NCT00481819

Locations: 🇨🇳
2 Sites, Shanghai, Shanghai, China
🇨🇳
3 Sites, Beijing, Beijing, China

Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia

Phase 2

Completed

Conditions: Leukemia

First Posted Date: 2007-04-11

Last Posted Date: 2019-02-15

Lead Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto

Target Recruit Count: 470

Registration Number: NCT00458848

Locations: 🇮🇹
Ospedale S. Donato, Arezzo, Italy
🇮🇹
S.G. Moscati Hospital, Avellino, Italy
🇮🇹
Ospedale Binaghi, Cagliari, Italy

and more 63 locations

a Phase II Study in Primary Central Nervous System Lymphoma

Phase 2

Conditions: Primary Central Nervous System Lymphoma

First Posted Date: 2007-04-03

Last Posted Date: 2007-04-04

Lead Sponsor: National Health Research Institutes, Taiwan

Target Recruit Count: 25

Registration Number: NCT00455286

Locations: 🇨🇳
Changhua Christian Hospital, Changhua, Taiwan
🇨🇳
China Medical University Hospital, Taichung, Taiwan
🇨🇳
National Cheng Kung University Hospital, TaiNan, Taiwan

and more 1 locations