Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicated in the treatment of pseudobulbar affect.

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

rhGH Therapy on Hepatic Drug Metabolism

Completed

Conditions: Growth Hormone Deficiency, Dwarfism

First Posted Date: 2007-04-11

Last Posted Date: 2017-04-27

Lead Sponsor: University of Louisville

Target Recruit Count: 9

Registration Number: NCT00458991

Locations: 🇺🇸
University of California at San Diego, San Diego, California, United States
🇺🇸
Children's Mercy Hospital and Clinics, Kansas City, Missouri, United States
🇺🇸
Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States

and more 1 locations

Treatment of Acute Sinusitis

Phase 4

Completed

Conditions: Acute Respiratory Infections
Acute Rhinosinusitis

Interventions: Drug: Acetaminophen
Drug: Amoxicillin
Drug: Dextromethorphan hydrobromide with guaifenesin
Drug: Guaifenesin
Drug: Pseudoephedrine Sustained Action
Drug: Saline spray (0.65%)

First Posted Date: 2006-09-18

Last Posted Date: 2012-12-28

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 172

Registration Number: NCT00377403

Locations: 🇺🇸
Washington University in St. Louis, St. Louis, Missouri, United States

Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents

Phase 2

Completed

Conditions: Healthy

First Posted Date: 2006-08-02

Last Posted Date: 2018-02-23

Lead Sponsor: Aegerion Pharmaceuticals, Inc.

Target Recruit Count: 125

Registration Number: NCT00359281

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

Hyperalgesia in Methadone Patients: Can it be Treated?

Phase 1

Conditions: Opioid-induced Hyperalgesia

First Posted Date: 2006-06-02

Last Posted Date: 2017-01-11

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 40

Registration Number: NCT00333242

Locations: 🇺🇸
UCLA School of Nursing, Los Angeles, California, United States

Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea

Not Applicable

Completed

Conditions: Sleep Apnea

Interventions: Drug: Dextromethorphan
Drug: Caffeine

First Posted Date: 2006-04-03

Last Posted Date: 2009-03-19

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 69

Registration Number: NCT00310323

Locations: 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity

Not Applicable

Terminated

Conditions: Neurotoxicity Syndromes

First Posted Date: 2005-09-15

Last Posted Date: 2009-12-11

Lead Sponsor: University of Medicine and Dentistry of New Jersey

Target Recruit Count: 20

Registration Number: NCT00176553

Locations: 🇺🇸
Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Dextromethorphan in Treating Patients With Fatigue Caused by Cancer

Not Applicable

Terminated

Conditions: Fatigue
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific

First Posted Date: 2005-09-15

Last Posted Date: 2011-05-17

Lead Sponsor: University of Medicine and Dentistry of New Jersey

Target Recruit Count: 30

Registration Number: NCT00176540

Locations: 🇺🇸
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States
🇺🇸
Cancer Institute of New Jersey at Hamilton, Hamilton, New Jersey, United States