Phenoxymethylpenicillin

Generic Name: Phenoxymethylpenicillin

Brand Names: Pen VK

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₈N_₂O_₅S

CAS Number: 87-08-1

Unique Ingredient Identifier: Z61I075U2W

Background: Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK. It is a phenoxymethyl analog of Penicillin G, or benzylpenicillin. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, skin, and soft tissues caused by penicillin...

Indication: Indicated for the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms, with the use of bacteriological studies (including sensitivity tests) and clinical response.

Phenoxymethylpenicillin may be used for the treatment of:

Off-label
...

Associated Conditions: Actinomycosis, Animal bite, Anthrax, Bacterial Endocarditis, Bacterial Infections, Community Acquired Pneumonia (CAP), Erythema Chronicum Migrans, Gingivitis, Necrotizing Ulcerative, Lower Respiratory Tract Infection (LRTI), Scarlet Fever, Skin and Subcutaneous Tissue Bacterial Infections, Streptococcal Pharyngitis, Tonsillitis streptococcal, Mild Otitis media, Mild bacterial upper respiratory tract infections, Moderate Otitis media, Moderate bacterial upper respiratory tract infections, Prophylaxis of Rheumatic fever

Associated Therapies: -

Clinical Trials

GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial

Phase 2

Recruiting

Conditions: Rheumatic Heart Disease

Interventions: Drug: phenoxymethyl penicillin
Drug: intramuscular benzathine penicillin G (BPG) prophylaxis

First Posted Date: 2023-01-23

Last Posted Date: 2024-12-12

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 1004

Registration Number: NCT05693545

Locations: 🇺🇬
Uganda Heart Institute, Kampala, Uganda

Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota

Phase 4

Completed

Conditions: Infectious Disease

Interventions: Drug: Amoxicillin
Drug: Amoxicillin-clavulanic acid
Drug: Phenoxymethylpenicillin

First Posted Date: 2019-09-10

Last Posted Date: 2022-12-02

Lead Sponsor: Uppsala University

Target Recruit Count: 104

Registration Number: NCT04084106

Locations: 🇸🇪
Uppsala University Hospital, Uppsala, Sweden

Sore Throat in Primary Care - a Comparison of Phenoxymethylpenicillin and No Antibiotic Treatment

Phase 4

Recruiting

Conditions: Sore Throat
Tonsillitis

Interventions: Drug: Phenoxymethylpenicillin
Other: No antibiotic treatment

First Posted Date: 2019-09-10

Last Posted Date: 2024-12-04

Lead Sponsor: Katarina Hedin

Target Recruit Count: 260

Registration Number: NCT04083417

Locations: 🇸🇪
Vårdcentralen Rosenhälsan, Jönköping, Sweden
🇸🇪
Vårdcentralen Kärna, Linköping, Sweden
🇸🇪
Vårdcentralen Lundbergsgatan, Malmö, Sweden

and more 3 locations

Minimally Invasive Sensing of Beta-lactam Antibiotics

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: Phenoxymethyl Penicillin
Device: Microneedle array

First Posted Date: 2019-02-20

Last Posted Date: 2024-03-27

Lead Sponsor: Imperial College London

Target Recruit Count: 11

Registration Number: NCT03847610

Locations: 🇬🇧
NIHR Imperial CRF, London, United Kingdom

Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia.

Phase 3

Terminated

Conditions: Community-acquired Pneumonia (CAP)

Interventions: Drug: Penicillin V
Drug: Amoxicillin

First Posted Date: 2017-07-05

Last Posted Date: 2017-07-05

Lead Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Target Recruit Count: 43

Registration Number: NCT03208361

Locations: 🇪🇸
IDIAP Jordi Gol, Barcelona, Spain

Penicillin for the Emergency Department Outpatient Treatment of CELLulitis

Phase 4

Conditions: Cellulitis
Wound Infection
Abscess

Interventions: Drug: Flucloxacillin
Drug: Placebo (for phenoxymethylpenicillin)
Drug: Phenoxymethylpenicillin

First Posted Date: 2016-10-04

Last Posted Date: 2016-10-04

Lead Sponsor: Royal College of Surgeons, Ireland

Target Recruit Count: 414

Registration Number: NCT02922686

Locations: 🇮🇪
Department of Emergency Medicine, Connolly Hospital,, Blanchardstown, Dublin, Ireland
🇮🇪
Department of Emergency Medicine, Mercy University Cork, Cork, Greenville Place, Ireland
🇮🇪
Beaumont Hospital,, Dublin, Ireland

and more 2 locations