Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Effects of Smoking on Opioid Receptor Binding: A PET Study

Phase 1

Completed

Conditions: Substance-related Discorder

First Posted Date: 2008-02-20

Last Posted Date: 2018-04-05

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 26

Registration Number: NCT00618631

Locations: 🇺🇸
Johns Hopkins Medical Institute, Baltimore, Maryland, United States
🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States

Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans

Early Phase 1

Completed

Conditions: Alcohol Consumption
Tobacco Use

Interventions: Drug: Nicotine
Drug: Ethanol

First Posted Date: 2008-02-15

Last Posted Date: 2014-07-08

Lead Sponsor: Yale University

Target Recruit Count: 18

Registration Number: NCT00616746

Locations: 🇺🇸
VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, United States

Nicotine and Behavior in Adult ADHD

Not Applicable

Completed

Conditions: ADHD

Interventions: Drug: Nicotine
Other: Placebo

First Posted Date: 2007-12-14

Last Posted Date: 2011-09-09

Lead Sponsor: University of California, Irvine

Target Recruit Count: 78

Registration Number: NCT00573248

Locations: 🇺🇸
Department of Pediatrics, Irvine, California, United States

Study of Nicotine for the Prevention of PONV

Phase 2

Terminated

Conditions: Postoperative Nausea and Vomiting

Interventions: Drug: Nicotine

First Posted Date: 2007-11-04

Last Posted Date: 2009-09-29

Lead Sponsor: University Hospital, Geneva

Target Recruit Count: 200

Registration Number: NCT00553709

Locations: 🇨🇭
Division of Anesthesiology, Geneva University Hospitals, Geneva, Switzerland

Study of Nicotine Patch in Pregnancy (SNIPP)

Phase 3

Completed

Conditions: Smoking

Interventions: Drug: nicotine versus placebo

First Posted Date: 2007-07-27

Last Posted Date: 2012-12-13

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 404

Registration Number: NCT00507975

Locations: 🇫🇷
Hopital La Pitie Salpetriere, Paris, France
🇫🇷
Groupe Hospitalier Pitié-Salpétrière, Unité de Recherche Clinique, Paris, France

Analysis of Aldehyde Biomarkers of Exposure and Host Response

Not Applicable

Terminated

Conditions: Smoking Cessation

Interventions: Drug: nicotine polacrilex
Drug: nicotine transdermal system
Drug: nicotine inhaler

First Posted Date: 2007-06-05

Last Posted Date: 2023-09-07

Lead Sponsor: University of Nebraska

Target Recruit Count: 35

Registration Number: NCT00482690

Locations: 🇺🇸
Unversity of Nebraska Medical Center, Omaha, Nebraska, United States

Validation of Biomarkers of Exposure and Host Response

Not Applicable

Completed

Conditions: Cigarette Smoker

First Posted Date: 2007-05-02

Last Posted Date: 2023-08-31

Lead Sponsor: University of Nebraska

Target Recruit Count: 60

Registration Number: NCT00468234

Locations: 🇺🇸
University of Nebraska Medical Center, Omaha, Nebraska, United States

Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers

Not Applicable

Conditions: Nicotine Dependence
Smoking
Tobacco Use Disorder
Nicotine Use Disorder

First Posted Date: 2007-01-31

Last Posted Date: 2007-01-31

Lead Sponsor: Hadassah Medical Organization

Target Recruit Count: 40

Registration Number: NCT00429208

Locations: 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel

Nicotine in Treating "Hunger Pain" in Patients With Malignant Bowel Obstruction Caused By Cancer

Not Applicable

Withdrawn

Conditions: Anorexia
Unspecified Adult Solid Tumor, Protocol Specific
Pain
Constipation, Impaction, and Bowel Obstruction
Psychosocial Effects of Cancer and Its Treatment

Interventions: Other: Placebo
Drug: nicotine
Procedure: Quality of life

First Posted Date: 2007-01-23

Last Posted Date: 2016-01-12

Lead Sponsor: Mayo Clinic

Registration Number: NCT00425906

Nicotine as an Adjuvant Analgesic for Third Molar Surgery

Phase 4

Completed

Conditions: Dental Crowding

Interventions: Drug: Nicotine
Other: Placebo

First Posted Date: 2006-10-09

Last Posted Date: 2020-11-24

Lead Sponsor: Columbia University

Target Recruit Count: 20

Registration Number: NCT00385216

Locations: 🇺🇸
Columbia University, New York, New York, United States

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