A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
Tongji Hospital,Tongji Medical College Affiliated,Huazhong University of Science & Technology, Wuhan, Hubei, China
Shun Lu, Shanghai, Shanghai, China
Augusta University, Georgia Cancer Center, Augusta, Georgia, United States
Florida Cancer Specialists - Fort Myers (Broadway), Fort Myers, Florida, United States
Florida Cancer Specialist, North Region, Saint Petersburg, Florida, United States
SCRI Florida Cancer Specialists PAN, Tallahassee, Florida, United States
University of Chicago Medicine, Chicago, Illinois, United States
Cancer Center at Saint Joseph's, Phoenix, Arizona, United States
Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States
Kaiser Permanente-Anaheim, Anaheim, California, United States
Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Hospital del Mar, Barcelona, Spain
ICO-Hospital Duran i Reynals, Bellvitge, Spain
Shanghai Pulmonary Hospital, Shanghai, Shanghai, China
M D Anderson Cancer Center, Houston, Texas, United States
Los Angeles General Medical Center, Los Angeles, California, United States
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania, United States
Stanford Cancer Center ( Site 0023), Palo Alto, California, United States
Northwestern Memorial Hospital ( Site 0002), Chicago, Illinois, United States
Texas Oncology-Plano East ( Site 0020), Plano, Texas, United States
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