Dexamethasone acetate
- Generic Name
- Dexamethasone acetate
- Drug Type
- Small Molecule
- Chemical Formula
- C24H31FO6
- CAS Number
- 1177-87-3
- Unique Ingredient Identifier
- K7V8P532WP
- Background
Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions. Developed in 1957, dexamethasone is structurally similar to other corticosteroids such as hydrocortisone and prednisolone. Dexamethasone acetate has largely been replaced by dexamethasone phosphate and continues to be administered for a large variety of inflammatory conditions.
Recently, dexamethasone has been a drug of interest in the treatment of COVID-19. In a June 16 2020 press release highlighting early results of a clinical trial, Randomized Evaluation of COVID-19 Therapy (RECOVERY), it was reported that dexamethasone reduced COVID-19 deaths by approximately one-fifth and one-third in patients on oxygen therapy and mechanical ventilation, respectively. Dexamethasone was therefore recommended as a life-saving treatment for COVID-19 patients experiencing severe respiratory symptoms.
- Associated Conditions
- Candida Albicans Vulvovaginitis, Dermatitis, Fungal Vaginal Infections
- Associated Therapies
- Corticosteroid therapy
Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009
- First Posted Date
- 2012-08-21
- Last Posted Date
- 2016-11-16
- Lead Sponsor
- UMC Utrecht
- Target Recruit Count
- 411
- Registration Number
- NCT01669499
- Locations
- 🇳🇱
Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands
🇳🇱University Medical Center Utrecht, Utrecht, Netherlands
Single Dose of Dexamethasone in Femur Fractures
- First Posted Date
- 2012-03-09
- Last Posted Date
- 2012-03-09
- Lead Sponsor
- Cork University Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT01550146
- Locations
- 🇮🇪
Cork University Hospital, Cork, Ireland
Vorinostat With Gemcitabine, Busulfan, and Melphalan With Stem Cell Transplant (SCT) in Relapsed or Refractory Lymphoid Malignancies
- Conditions
- Lymphoma
- Interventions
- First Posted Date
- 2011-08-22
- Last Posted Date
- 2015-11-18
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 78
- Registration Number
- NCT01421173
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Early Treatment With Dexamethasone in Mild Acute Pancreatitis
- Conditions
- Patients With Acute Pancreatitis
- Interventions
- Other: Placebo
- First Posted Date
- 2010-11-25
- Last Posted Date
- 2016-12-12
- Lead Sponsor
- Brigham and Women's Hospital
- Registration Number
- NCT01247961
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Effects of Steroid Tapering on Functional Capacity and Neurocognition
- Conditions
- Glioblastoma Multiforme
- Interventions
- First Posted Date
- 2010-07-26
- Last Posted Date
- 2014-05-19
- Lead Sponsor
- Duke University
- Registration Number
- NCT01169415
Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
- Conditions
- Leukemia
- Interventions
- First Posted Date
- 2008-04-02
- Last Posted Date
- 2021-08-18
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 717
- Registration Number
- NCT00651261
- Locations
- 🇺🇸
St. Luke's Regional Medical Center, Sioux City, Iowa, United States
🇺🇸Ministry Saint Clare's Hospital, Weston, Wisconsin, United States
🇺🇸Cancer Centers of the Carolinas - Easley, Easley, South Carolina, United States
Anakinra With or Without Dexamethasone in Treating Patients With Smoldering or Indolent Multiple Myeloma
- Conditions
- Multiple Myeloma and Plasma Cell Neoplasm
- Interventions
- Biological: Anakinra (IL-1Ra)
- First Posted Date
- 2008-03-13
- Last Posted Date
- 2018-06-07
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 55
- Registration Number
- NCT00635154
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Drug Development Updates
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