Minocycline

Generic Name
Minocycline
Brand Names
Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
Drug Type
Small Molecule
Chemical Formula
C23H27N3O7
CAS Number
10118-90-8
Unique Ingredient Identifier
FYY3R43WGO
Background

Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
...

Indication

Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...

Associated Conditions
Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
Associated Therapies
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Clinical Trials
Related News

The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients

Not Applicable
Conditions
Epileptic Seizures Related to Drugs
Interventions
Drug: minocycline
First Posted Date
2023-07-24
Last Posted Date
2023-07-24
Lead Sponsor
Xijing Hospital
Target Recruit Count
25
Registration Number
NCT05958069
Locations
🇨🇳

XijingHospital, Xi'an, Shaanxi, China

Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories

First Posted Date
2023-06-15
Last Posted Date
2023-12-21
Lead Sponsor
Psychiatric University Hospital, Zurich
Target Recruit Count
180
Registration Number
NCT05902819
Locations
🇨🇭

Psychiatric University Hospital Zurich, University of Zurich, Zürich, Switzerland

Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease

First Posted Date
2023-05-16
Last Posted Date
2024-11-18
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
15
Registration Number
NCT05861258
Locations
🇳🇱

Radboud University Medical Center, Nijmegen, Gelderland, Netherlands

Antibiotics Against Amyloid Angiopathy

Phase 1
Recruiting
Conditions
Cerebral Amyloid Angiopathy
Interventions
Drug: Placebo
Drug: Minocycline
First Posted Date
2023-01-11
Last Posted Date
2023-01-11
Lead Sponsor
Leiden University Medical Center
Target Recruit Count
60
Registration Number
NCT05680389
Locations
🇳🇱

Leiden University Medical Center, Leiden, Netherlands

INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder

First Posted Date
2022-12-09
Last Posted Date
2024-10-14
Lead Sponsor
Universiteit Antwerpen
Target Recruit Count
240
Registration Number
NCT05644301
Locations
🇧🇪

UPC Duffel, Duffel, Antwerpen, Belgium

🇧🇪

UZ Brussel, Brussels, Belgium

🇧🇪

Katholiek Universiteit Leuven Campus Kortenberg, Leuven, Belgium

Minocycline Accelerates Intracerebral Hemorrhage Absorption

Phase 1
Not yet recruiting
Conditions
Intracerebral Hemorrhage
Interventions
Drug: Minocycline
Other: starch
First Posted Date
2022-11-29
Last Posted Date
2022-11-29
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Target Recruit Count
90
Registration Number
NCT05630534

Minocycline in Neurocognitive Outcomes - Sickle Cell Disease

First Posted Date
2022-11-04
Last Posted Date
2024-12-06
Lead Sponsor
University of Cincinnati
Target Recruit Count
30
Registration Number
NCT05605366

Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection

First Posted Date
2022-10-19
Last Posted Date
2023-01-18
Lead Sponsor
Mahidol University
Target Recruit Count
94
Registration Number
NCT05586815
Locations
🇹🇭

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections

First Posted Date
2022-10-12
Last Posted Date
2023-01-10
Lead Sponsor
Mahidol University
Target Recruit Count
112
Registration Number
NCT05575427
Locations
🇹🇭

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)

First Posted Date
2022-08-23
Last Posted Date
2022-12-16
Lead Sponsor
Xijing Hospital
Target Recruit Count
90
Registration Number
NCT05512910
Locations
🇨🇳

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China

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