Coenzyme M
- Generic Name
- Coenzyme M
- Brand Names
- Uromitexan
- Drug Type
- Small Molecule
- Chemical Formula
- C2H6O3S2
- CAS Number
- 3375-50-6
- Unique Ingredient Identifier
- VHD28S0H7F
- Background
Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.
- Indication
Mesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis.
- Associated Conditions
- Hemorrhagic cystitis caused by cyclophosphamide, Hemorrhagic cystitis caused by ifosfamide
- Associated Therapies
- -
Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia
- Conditions
- First Posted Date
- 2004-06-16
- Last Posted Date
- 2014-07-24
- Lead Sponsor
- Children's Oncology Group
- Registration Number
- NCT00002785
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇺🇸Ireland Cancer Center, Cleveland, Ohio, United States
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma
- Conditions
- Interventions
- Biological: filgrastimDrug: carboplatinDrug: cyclophosphamideDrug: doxorubicin hydrochlorideDrug: etoposideDrug: mesnaDrug: vincristine sulfateProcedure: conventional surgeryProcedure: peripheral blood stem cell transplantationRadiation: low-LET cobalt-60 gamma ray therapyRadiation: low-LET photon therapy
- First Posted Date
- 2004-06-16
- Last Posted Date
- 2014-07-24
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 30
- Registration Number
- NCT00002740
- Locations
- 🇺🇸
Children's Hospital of Columbus, Columbus, Ohio, United States
🇺🇸Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington, United States
🇺🇸UCSF Cancer Center and Cancer Research Institute, San Francisco, California, United States
Bone Marrow Transplantation in Treating Patients With Lymphoma
- First Posted Date
- 2004-05-26
- Last Posted Date
- 2012-07-30
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 45
- Registration Number
- NCT00002829
- Locations
- 🇺🇸
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
- First Posted Date
- 2004-05-24
- Last Posted Date
- 2014-08-01
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 421
- Registration Number
- NCT00002875
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
🇺🇸Ireland Cancer Center, Cleveland, Ohio, United States
Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia
- First Posted Date
- 2004-05-19
- Last Posted Date
- 2013-10-16
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 43
- Registration Number
- NCT00002961
- Locations
- 🇺🇸
Cardinal Glennon Children's Hospital, Saint Louis, Missouri, United States
🇺🇸Nemours Children's Clinic, Jacksonville, Florida, United States
🇺🇸Children's Mercy Hospital, Kansas City, Missouri, United States
Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma
- Conditions
- First Posted Date
- 2004-05-12
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 500
- Registration Number
- NCT00002802
- Locations
- 🇩🇪
University of Cologne, Frechen, Germany
Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma
- Conditions
- First Posted Date
- 2004-05-05
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- University Hospital Muenster
- Registration Number
- NCT00002516
- Locations
- 🇬🇧
Royal Victoria Infirmary, Newcastle-upon-Tyne, England, United Kingdom
Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
- Conditions
- Interventions
- Drug: cyclophosphamideDrug: cytarabineDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: etoposideDrug: ifosfamideDrug: leucovorin calciumDrug: mesnaDrug: methotrexateDrug: prednisoneDrug: therapeutic hydrocortisoneDrug: vincristine sulfateRadiation: low-LET cobalt-60 gamma ray therapyRadiation: low-LET photon therapy
- First Posted Date
- 2004-04-06
- Last Posted Date
- 2016-07-04
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 134
- Registration Number
- NCT00002494
- Locations
- 🇺🇸
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States
🇺🇸University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, United States
🇺🇸Ellis Fischel Cancer Center - Columbia, Columbia, Missouri, United States
Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus
- Conditions
- Interventions
- First Posted Date
- 2004-02-03
- Last Posted Date
- 2021-01-05
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 9
- Registration Number
- NCT00076752
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Randomized Double Cord Blood Transplant Study
- Conditions
- Interventions
- First Posted Date
- 2003-08-11
- Last Posted Date
- 2019-05-01
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 110
- Registration Number
- NCT00067002
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Drug Development Updates
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