Clindamycin

Generic Name: Clindamycin

Brand Names: Acanya, Benzaclin, Biacna, Cabtreo, Cleocin, Cleocin-T, Clindacin, Clindagel, Clindesse, Clindoxyl, Dalacin, Dalacin C, Duac, Evoclin, Neuac, Onexton, Veltin, Xaciato, Ziana

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₃₃ClN_₂O_₅S

CAS Number: 18323-44-9

Unique Ingredient Identifier: 3U02EL437C

Background: Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli. Interestingly, clindamy...

Indication: In oral and parenteral formulations, clindamycin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, as well as susceptible staphylococci, streptococci, and pneumococci. Used topically, it is indicated for the treatment of acne vulgaris and is available in combination with benzoyl peroxide or tretinoin for this purp...

Associated Conditions: Abscess, Intra-Abdominal caused by Anaerobic Bacterial Infection, Acne Vulgaris, Babesiosis, Bacterial Endocarditis, Bacterial Vaginosis (BV), Bloodstream Infections caused by Anaerobic Bacterial Infection, Bone and Joint Infections caused by susceptible Staphylococcus, Empyema caused by Anaerobic Bacterial Infection, Endometritis caused by Anaerobic Bacterial Infection, Lung Abscess caused by Anaerobic Bacterial Infection, Malaria caused by Plasmodium falciparum, Mixed Vaginal Infections, Pelvic cellulitis caused by Anaerobic Bacterial Infection, Peritonitis caused by Anaerobic Bacterial Infection, Pneumocystis Jirovecii Pneumonia, Pneumonitis caused by Anaerobic Bacterial Infection, Respiratory Tract Infections (RTI) caused by susceptible Staphylococcus, Respiratory Tract Infections (RTI) caused by susceptible pneumococci, Respiratory Tract Infections (RTI) caused by susceptible streptococci, Septicemia caused by susceptible Staphylococcus, Septicemia caused by susceptible streptococci, Skin Structures and Soft Tissue Infections caused by Anaerobic Bacterial Infection, Skin Structures and Soft Tissue Infections caused by susceptible Staphylococcus, Skin Structures and Soft Tissue Infections caused by susceptible streptococci, Toxoplasmosis, Tubo-ovarian abscess caused by Anaerobic Bacterial Infection, Vaginal Candidiasis, Vaginal Mycosis, Chronic Bone and Joint Infections caused by Susceptible infections, Moderate Acne vulgaris, Post-surgical vaginal cuff infection caused by Anaerobic Bacterial Infection, Viridans group streptococci

Associated Therapies: -

Clinical Trials

Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial

Not Applicable

Conditions: Endometritis

Interventions: Drug: Antibiotic prophylaxis
Drug: Ampicillin
Drug: Gentamycin
Drug: Clindamycin

First Posted Date: 2013-09-18

Last Posted Date: 2013-11-27

Lead Sponsor: Hadassah Medical Organization

Target Recruit Count: 300

Registration Number: NCT01945450

Locations: 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel

Adjunctive Clindamycin for Cellulitis: C4C Trial.

Phase 4

Completed

Conditions: Cellulitis

Interventions: Drug: Flucloxacillin
Drug: Placebo oral capsule
Drug: Clindamycin

First Posted Date: 2013-06-12

Last Posted Date: 2022-08-17

Lead Sponsor: University Hospitals Bristol and Weston NHS Foundation Trust

Target Recruit Count: 410

Registration Number: NCT01876628

Locations: 🇬🇧
University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom

Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients

Phase 2

Completed

Conditions: Colorectal Cancer
Head and Neck Cancer

Interventions: Drug: Doxycycline
Drug: Hydrocortisone 1% cream
Other: Sunscreen
Other: Moisturizer
Drug: Clindamycin
Drug: Medrol-dose pack (Steroid)

First Posted Date: 2013-06-11

Last Posted Date: 2022-12-01

Lead Sponsor: University of Louisville

Target Recruit Count: 24

Registration Number: NCT01874860

Locations: 🇺🇸
James Graham Brown Cancer Center, Louisville, Kentucky, United States

Clindamycin to Reduce Preterm Birth in a Low Resource Setting

Phase 4

Completed

Conditions: Pregnancy
Prematurity
Preterm Birth
Bacterial Vaginosis

Interventions: Drug: Placebo
Drug: Clindamycin

First Posted Date: 2013-02-28

Last Posted Date: 2016-07-18

Lead Sponsor: Christiana Care Health Services

Target Recruit Count: 1726

Registration Number: NCT01800825

Locations: 🇮🇳
Jawaharlal Nehru Medical College, Belgaum, Karnataka, India

Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

Phase 3

Completed

Conditions: Staphylococcus Aureus Infection

Interventions: Drug: Trimethoprim-Sulfamethoxazole
Drug: Flucloxacillin
Drug: Clindamycin
Drug: Cloxacillin
Drug: Linezolid
Drug: Vancomycin
Drug: Daptomycin
Drug: Cefazolin

First Posted Date: 2013-02-15

Last Posted Date: 2020-05-27

Lead Sponsor: Heinrich-Heine University, Duesseldorf

Target Recruit Count: 215

Registration Number: NCT01792804

Locations: 🇳🇱
Amsterdam, Amsterdam, Netherlands
🇳🇱
Tilburg, Tilburg, Netherlands
🇳🇱
Diakonessenhuis Utrecht, Utrecht, Netherlands

and more 37 locations

Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

Phase 2

Conditions: Hip Prosthetic Joint Infection

Interventions: Drug: VANCOMYCIN
Drug: CEFTRIAXONE
Drug: LINEZOLID
Drug: CLINDAMYCIN
Drug: SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE)
Drug: FLUOROQUINOLONE
Drug: RIFAMPIN

First Posted Date: 2012-12-28

Last Posted Date: 2014-05-28

Lead Sponsor: University Hospital, Tours

Target Recruit Count: 100

Registration Number: NCT01757236

Locations: 🇫🇷
CHRU de Tours, Tours, Indre et Loire, France
🇮🇹
Azienda Opedaliera Universitaria San Maria della Misericordia, Udine, Italy
🇫🇷
CHU de Nantes, Nantes, France

and more 6 locations

Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile

Phase 1

Completed

Conditions: Bacterial Infections
Obesity

Interventions: Drug: Clindamycin

First Posted Date: 2012-12-07

Last Posted Date: 2016-11-29

Lead Sponsor: Phillip Brian Smith

Target Recruit Count: 22

Registration Number: NCT01744730

Locations: 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸
Children's Mercy Hospital, Kansas City, Kansas, United States
🇺🇸
Akron Children's Hospital, Akron, Ohio, United States

and more 1 locations

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies

Not Applicable

Recruiting

Conditions: High Risk Pregnancies for Preterm Labor
Abnormal Vaginal Flora
Clindamycin Vs Metronidazole

Interventions: Drug: Clindamycin
Drug: Metronidazole

First Posted Date: 2012-11-07

Last Posted Date: 2024-06-21

Lead Sponsor: HaEmek Medical Center, Israel

Target Recruit Count: 750

Registration Number: NCT01722708

Locations: 🇮🇱
Departement of obstetric and gynecology, Poriya Medical Center, Tiberias, Israel
🇮🇱
Departement of obstetric and gynecology, HaEmek medical center, Afula, Israel

Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage

Not Applicable

Withdrawn

Conditions: Peritonsillar Abscess

Interventions: Drug: Randomization to Placebo
Drug: Clavulin
Drug: Clindamycin

First Posted Date: 2012-10-29

Last Posted Date: 2017-11-06

Lead Sponsor: Lawson Health Research Institute

Registration Number: NCT01715610

Locations: 🇨🇦
London Health Sciences Center, St. Joseph's Hospital, London, Ontario, Canada

Antibiotic Prophylaxis for Simple Hand Lacerations

Not Applicable

Terminated

Conditions: Simple Hand Lacerations

Interventions: Drug: cephalexin
Drug: placebo
Drug: clindamycin

First Posted Date: 2010-07-01

Last Posted Date: 2014-11-07

Lead Sponsor: State University of New York - Downstate Medical Center

Target Recruit Count: 73

Registration Number: NCT01155154

Locations: 🇺🇸
Kings County Hospital Center, Brooklyn, New York, United States
🇺🇸
Staten Island University Hospital, Staten Island, New York, United States
🇺🇸
State University of New York, Downstate Medical Center, Brooklyn, New York, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy