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HSA Approval

NUTRINEAL PD4 WITH 1.1% AMINO ACID SOLUTION

SIN09353P

NUTRINEAL PD4 WITH 1.1% AMINO ACID SOLUTION

NUTRINEAL PD4 WITH 1.1% AMINO ACID SOLUTION

May 27, 1997

BAXTER HEALTHCARE (ASIA) PTE LTD

BAXTER HEALTHCARE (ASIA) PTE LTD

Regulatory Information

BAXTER HEALTHCARE (ASIA) PTE LTD

BAXTER HEALTHCARE (ASIA) PTE LTD

Therapeutic

General Sale List

Formulation Information

SOLUTION, STERILE

2\. **Dosage and Method of Administration** Administration: - NUTRINEAL is intended for intraperitoneal administration only. Not for intravenous administration. - The intraperitoneal administration route requires the use of a specific peritoneal dialysis catheter and an appropriate administration set which connects the solution container to the patient's catheter. - NUTRINEAL should be administered at a rate that is comfortable for the patient. The volume administered is determined by the prescribing physician. - The mode of therapy, frequency of treatment, exchange volume, duration of dwell and length of dialysis should be initiated and supervised by the prescribing physician. - Treatment should be re-evaluated after 3 months if there is no clinical or biochemical improvement in the status of the patient. - Do not remove unit from over pouch until ready for use. - Peritoneal dialysis solutions may be warmed in the overpouch to 37°C (98.6°F) to enhance patient comfort. However, only dry heat (for example, heating pad, warming plate) should be used. Solutions should not be heated in water or in a microwave oven due to the potential for patient injury or discomfort. - Aseptic technique should be employed through the peritoneal dialysis procedure. - Do not administer unless the solution is clear and free of particulate matter. - In case of damage, the container should be discarded. - Discard any unused remaining solution - For single use only Dosage: - Dosage schedule, frequency of treatment and duration of dwell should be selected by the prescribing physician according to the patient's clinical status. - Recommended dietary allowance of protein is approximately 1.2–1.3 g/kg for dialysed adults and 2–3 g/kg for infants. Higher amounts may be necessary in several catabolic states. - For information, a 2-litre bag of Nutrineal with 1.1% amino acids provides 22g of amino acids which are equivalent to 0.30g/kg/day for a 70kg adult. - Safety and effectiveness in pediatric patients has not been established.

INTRAPERITONEAL

Medical Information

1\. **Therapeutic Indications** Nutritional supplement for malnourished renal failure patients (albumin concentration lower than 35g/litre) being maintained on peritoneal dialysis.

3\. **Contraindication** NUTRINEAL is contraindicated in patients with: - known hypersensitivity to any amino acids in the product or to any of the excipients - Serum urea level above 38mmol/L - uremic symptoms - metabolic acidosis - inborn errors of amino acid metabolism - liver insufficiency - severe hypokalemia - uncorrectable mechanical defects that prevent effective PD or increase the risk of infection - documented loss of peritoneal function or extensive adhesions that compromise peritoneal function

B05DA

等渗溶液

Manufacturer Information

BAXTER HEALTHCARE (ASIA) PTE LTD

BAXTER HEALTHCARE SA, SINGAPORE BRANCH

BAXTER HEALTHCARE SA

Active Ingredients

L-ISOLEUCINE

0.85 g/l

Isoleucine

L-VALINE

1.393 g/l

Valine

CALCIUM CHLORIDE DIHYDRATE

0.184 g/l

Calcium chloride

MAGNESIUM CHLORIDE HEXAHYDRATE

0.051 g/l

Magnesium chloride

L-SERINE

0.51 g/l

Serine

GLYCINE

0.51 g/l

Glycine

L-TRYPTOPHAN

0.27 g/l

Tryptophan

SODIUM LACTATE

4.48 g/l

Lactic acid

L-LYSINE (as HCl)

0.955 g/l

Lysine

SODIUM CHLORIDE

5.38 g/l

Sodium chloride

L-PHENYLALANINE

0.57 g/l

Phenylalanine

L-METHIONINE

0.85 g/l

Methionine

L-TYROSINE

0.3 g/l

Tyrosine

L-PROLINE

0.595 g/l

Proline

L-THREONINE

0.646 g/l

Threonine

L-HISTIDINE

0.714 g/l

Histidine

L-ARGININE

1.071 g/l

L-arginine

L-LEUCINE

1.02 g/l

Leucine

L-ALANINE

0.951 g/l

Alanine

Documents

Package Inserts

Nutrineal PI.pdf

Approved: November 11, 2015

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