Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
- Conditions
- Interventions
- First Posted Date
- 2004-09-22
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 75
- Registration Number
- NCT00092222
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2004-06-09
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Centro di Riferimento Oncologico - Aviano
- Target Recruit Count
- 20
- Registration Number
- NCT00002905
- Locations
- 🇮🇹
Centro di Riferimento Oncologico - Aviano, Aviano, Italy
Strategies for Delivering Anti-HIV Therapy in South Africa
- Conditions
- First Posted Date
- 2004-04-07
- Last Posted Date
- 2007-09-18
- Target Recruit Count
- 813
- Registration Number
- NCT00080522
- Locations
- 🇿🇦
University of the Witwatersrand/Clinical HIV Research Unit, Johannesburg, Gauteng, South Africa
🇿🇦University of Cape Town/Masiphumelele, Cape Town, South Peninsula, South Africa
Anti-HIV Drugs for Ugandan Patients With HIV and Tuberculosis
- Conditions
- Interventions
- First Posted Date
- 2004-02-23
- Last Posted Date
- 2010-08-12
- Target Recruit Count
- 350
- Registration Number
- NCT00078247
- Locations
- 🇺🇬
Makerere University Medical School, Kampala, Uganda
Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Centro di Riferimento Oncologico - Aviano
- Target Recruit Count
- 14
- Registration Number
- NCT00003261
- Locations
- 🇮🇹
Centro di Riferimento Oncologico - Aviano, Aviano, Italy
Zidovudine Plus Interleukin-2 and Ganciclovir in Treating Patients With AIDS-Related Primary Central Nervous System Lymphoma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2016-02-03
- Lead Sponsor
- AIDS Malignancy Consortium
- Registration Number
- NCT00006264
- Locations
- 🇺🇸
Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, United States
🇺🇸Sylvester Cancer Center, University of Miami, Miami, Florida, United States
Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2016-02-03
- Lead Sponsor
- AIDS Malignancy Consortium
- Target Recruit Count
- 19
- Registration Number
- NCT00041327
- Locations
- 🇺🇸
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
🇺🇸University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, United States
🇺🇸Siteman Cancer Center at Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients
- Conditions
- First Posted Date
- 2003-01-01
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 775
- Registration Number
- NCT00050895
- Locations
- 🇺🇸
IHV Baltimore Treatment CRS, Baltimore, Maryland, United States
🇺🇸UCLA CARE Center CRS, Los Angeles, California, United States
🇺🇸Univ. of Miami AIDS CRS, Miami, Florida, United States
A Randomized Pilot Study for the Treatment of AIDS or AIDS Related Complex With an Alternating or Simultaneous Combination Regimen of AZT and 2',3'-Dideoxyinosine
- Conditions
- First Posted Date
- 2002-12-10
- Last Posted Date
- 2008-03-04
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 42
- Registration Number
- NCT00001267
- Locations
- 🇺🇸
National Cancer Institute (NCI), Bethesda, Maryland, United States
Study of Anti-HIV Therapy Intensification
- Conditions
- First Posted Date
- 2002-04-23
- Last Posted Date
- 2012-05-18
- Target Recruit Count
- 22
- Registration Number
- NCT00034086
- Locations
- 🇺🇸
Rush Univ. Med. Ctr. ACTG CRS, Chicago, Illinois, United States
🇺🇸Case CRS, Cleveland, Ohio, United States
🇺🇸University of Colorado Hospital CRS, Aurora, Colorado, United States
Drug Development Updates
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