Zidovudine

Generic Name
Zidovudine
Brand Names
Combivir, Retrovir, Trizivir
Drug Type
Small Molecule
Chemical Formula
C10H13N5O4
CAS Number
30516-87-1
Unique Ingredient Identifier
4B9XT59T7S
Background

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...

Indication

Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.

Associated Conditions
HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
Associated Therapies
-

A Study of Zidovudine in HIV-Infected Patients With Liver Disease

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
39
Registration Number
NCT00001001
Locations
🇺🇸

Univ of Massachusetts Med Ctr, Worcester, Massachusetts, United States

🇺🇸

Boston Med Ctr, Boston, Massachusetts, United States

🇺🇸

Univ of Washington, Seattle, Washington, United States

and more 2 locations

The Safety and Effectiveness of Hyperimmune Anti-HIV Intravenous Immunoglobulin (HVIG) Plus Zidovudine in HIV-Infected Infants

Phase 2
Terminated
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
112
Registration Number
NCT00000961

A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
482
Registration Number
NCT00000700
Locations
🇺🇸

Johns Hopkins Hosp, Baltimore, Maryland, United States

🇺🇸

Harvard (Massachusetts Gen Hosp), Boston, Massachusetts, United States

🇺🇸

Beth Israel Deaconess - West Campus, Boston, Massachusetts, United States

and more 25 locations

The Safety and Effectiveness of Zidovudine in the Treatment of HIV-Infected Children With Mild to Moderate Symptoms

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
224
Registration Number
NCT00000990
Locations
🇺🇸

Milton S Hershey Med Ctr, Hershey, Pennsylvania, United States

🇺🇸

City Hosp Ctr at Elmhurst / Mount Sinai Hosp, Elmhurst, New York, United States

🇺🇸

Bellevue Hosp / New York Univ Med Ctr, New York, New York, United States

and more 29 locations

A Phase I Evaluation of Azidothymidine (AZT) in Children With Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
12
Registration Number
NCT00000701
Locations
🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

🇺🇸

Duke Univ Med Ctr, Durham, North Carolina, United States

Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV Infection

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
55
Registration Number
NCT00000872
Locations
🇺🇸

Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases, Baltimore, Maryland, United States

🇺🇸

Univ. of Maryland Med. Ctr., Div. of Ped. Immunology & Rheumatology, Baltimore, Maryland, United States

🇺🇸

BMC, Div. of Ped Infectious Diseases, Boston, Massachusetts, United States

and more 9 locations

A Study of Zidovudine During Labor and Delivery in HIV-Infected Pregnant Women

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
36
Registration Number
NCT00000862
Locations
🇺🇸

UCSD Med Ctr / Pediatrics / Clinical Sciences, La Jolla, California, United States

🇺🇸

Saint Jude Children's Research Hosp of Memphis, Memphis, Tennessee, United States

🇺🇸

Children's Hosp of the King's Daughters, Norfolk, Virginia, United States

and more 8 locations

The Safety and Effectiveness of Zidovudine in HIV-Infected Pregnant Women and Their Infants

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1496
Registration Number
NCT00000960
Locations
🇺🇸

Los Angeles County - USC Med Ctr, Los Angeles, California, United States

🇵🇷

Univ of Puerto Rico / Univ Children's Hosp AIDS, San Juan, Puerto Rico

🇺🇸

Univ of Massachusetts Med Ctr, Worcester, Massachusetts, United States

and more 59 locations

A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 Infection

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
85
Registration Number
NCT00000823
Locations
🇺🇸

Illinois Masonic Med Ctr, Chicago, Illinois, United States

🇺🇸

Harvard (Massachusetts Gen Hosp), Boston, Massachusetts, United States

🇺🇸

Univ of Alabama at Birmingham, Birmingham, Alabama, United States

and more 19 locations

A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)

First Posted Date
2001-08-31
Last Posted Date
2021-11-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
322
Registration Number
NCT00000727
Locations
🇺🇸

University of Washington AIDS CRS, Seattle, Washington, United States

🇺🇸

Bmc Actg Crs, Boston, Massachusetts, United States

🇺🇸

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States

and more 6 locations
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