Ceftriaxone

Generic Name: Ceftriaxone

Brand Names: Rocephin

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₈N_₈O_₇S_₃

CAS Number: 73384-59-5

Unique Ingredient Identifier: 75J73V1629

Background: Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S...

Indication: Ceftriaxone is used for the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by susceptible organisms. Organisms that are generally susceptible to ceftriaxone include S. pneumoniae, S. pyogenes (group A beta-hemolytic streptococci), coagulase-negative staphylococci, Some Enterobacter spp, H. influenzae, N. gonorrhoeae, P. mirabil...

Associated Conditions: Abscess Brain, Bacterial Endocarditis, Bacterial Infections, Bacterial Sinusitis, Bone and Joint Infections, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal arthritis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intraabdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infections, Sepsis Bacterial, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Urinary Tract Infection caused by susceptible bacteria, Disease caused by Salmonella typhi, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial

Associated Therapies: -

Clinical Trials

Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis

Phase 2

Completed

Conditions: Ulcerative Colitis
Inflammatory Bowel Diseases
Acute Severe Colitis

Interventions: Other: Placebo infusion
Drug: Ceftriaxone
Drug: Metronidazole

First Posted Date: 2019-01-07

Last Posted Date: 2020-12-11

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 50

Registration Number: NCT03794765

Locations: 🇮🇳
Postgraduate Institute of Medical Education and Research, Chandigarh, India

Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

Phase 4

Terminated

Conditions: Post-Op Wound Infection
Open Fracture

Interventions: Drug: Piperacillin/tazobactam
Drug: Clindamycin + Gentamicin
Drug: Ampicillin/sulbactam
Drug: Cefazolin + Gentamicin
Drug: Ceftriaxone

First Posted Date: 2018-06-18

Last Posted Date: 2020-09-11

Lead Sponsor: Mercy Health Ohio

Target Recruit Count: 17

Registration Number: NCT03560232

Locations: 🇺🇸
St. Joseph Warren Hospital, Warren, Ohio, United States
🇺🇸
St. Elizabeth Youngstown Hospital, Youngstown, Ohio, United States

Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair

Not Applicable

Completed

Conditions: Erectile Dysfunction

Interventions: Procedure: Immediate repair
Procedure: Delayed repair
Drug: Ceftriaxone
Drug: Lidocaine
Drug: Diclofenac Sodium

First Posted Date: 2018-02-28

Last Posted Date: 2018-03-01

Lead Sponsor: Ministry of Health, Jamaica

Target Recruit Count: 46

Registration Number: NCT03449940

Locations: 🇯🇲
Kingston Public Hospital, Kingston, Jamaica
🇯🇲
University Hospital of the West Indies, Kingston, Jamaica

To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia

Phase 2

Recruiting

Conditions: Parkinson's Disease Dementia

Interventions: Other: Placebo
Drug: Ceftriaxone

First Posted Date: 2018-01-29

Last Posted Date: 2023-10-16

Lead Sponsor: BrainX Corporation

Target Recruit Count: 106

Registration Number: NCT03413384

Locations: 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
🇨🇳
China Medical University Hospital, Taichung, Taiwan
🇨🇳
Changhua Christian Hospital, Changhua, Taiwan

and more 3 locations

New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea

Phase 3

Completed

Conditions: Gonorrhea

Interventions: Drug: Gentamicin Sulfate, Injectable
Drug: Ertapenem 1000 MG
Drug: Fosfomycin Oral Suspension
Drug: Ceftriaxone

First Posted Date: 2017-09-27

Last Posted Date: 2021-08-06

Lead Sponsor: Public Health Service of Amsterdam

Target Recruit Count: 346

Registration Number: NCT03294395

Locations: 🇳🇱
Public Health Service, Amsterdam, Noord Holland, Netherlands

Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis

Phase 4

Completed

Conditions: Pyelonephritis Acute

Interventions: Drug: Ceftriaxone

First Posted Date: 2017-06-07

Last Posted Date: 2023-11-18

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Target Recruit Count: 9

Registration Number: NCT03179384

Locations: 🇫🇷
CHU de Nice, Nice, France

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition

Phase 3

Conditions: Antibiotic Resistance
Malnutrition Severe
Antibiotic Toxicity

Interventions: Drug: Benzyl penicillin
Other: Placebo
Drug: Ceftriaxone
Drug: Metronidazole
Drug: Gentamicin

First Posted Date: 2017-06-02

Last Posted Date: 2020-05-19

Lead Sponsor: University of Oxford

Target Recruit Count: 2000

Registration Number: NCT03174236

Locations: 🇰🇪
Mbagathi Hospital, Nairobi, Kenya
🇰🇪
Coast General Hospital - Study site, Mombasa, Kenya
🇰🇪
Mbagathi District Hospital, Nairobi, Kenya

and more 4 locations