Sugammadex
- Generic Name
- Sugammadex
- Brand Names
- Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
- Drug Type
- Small Molecule
- Chemical Formula
- C72H112O48S8
- CAS Number
- 343306-71-8
- Unique Ingredient Identifier
- 361LPM2T56
- Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
- Indication
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
- Associated Conditions
- Neuromuscular blockade caused by vecuronium bromide
Neostigmine/Glyco-pyrrolate 50 Mikrogram/kg or Sugammadex 2 mg/kg for Reversal of Neuromuscular Blockade in Elderly Patients
- Conditions
- Neuromuscular Blockade, Residual
- Interventions
- Drug: neostigmine/glycopyrrolate
- First Posted Date
- 2024-01-29
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- Matias Vested
- Target Recruit Count
- 40
- Registration Number
- NCT06228092
- Locations
- 🇩🇰
Department of anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark
🇩🇰Bispebjerg Hospital, Copenhagen, Denmark
🇩🇰Department of Pediatric and Obstetric Anaesthesia, Rigshospitalet, Copenhagen, Denmark
Muscle Relaxation for Pediatric Adenotonsillectomy
- Conditions
- Tonsillectomy
- Interventions
- First Posted Date
- 2024-01-26
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 172
- Registration Number
- NCT06225466
- Locations
- 🇺🇸
Children's Health Dallas, Dallas, Texas, United States
Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery
- Conditions
- Atelectasis, PostoperativePulmonary Function; Newborn, Abnormal
- Interventions
- First Posted Date
- 2024-01-18
- Last Posted Date
- 2024-01-18
- Lead Sponsor
- Rhendra Hardy Mohamad Zaini
- Target Recruit Count
- 80
- Registration Number
- NCT06210165
- Locations
- 🇲🇾
University of Science Malaysia Hospital, Kubang Kerian, Kelantan, Malaysia
Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial
- Conditions
- Neuromuscular Blocks
- Interventions
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2024-07-01
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 80
- Registration Number
- NCT06136585
- Locations
- 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
- Conditions
- Intestinal Disease
- Interventions
- First Posted Date
- 2023-11-01
- Last Posted Date
- 2024-08-12
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 128
- Registration Number
- NCT06112353
- Locations
- 🇺🇸
UC Irvine Medical Center, Orange, California, United States
Neostigmine Versus Sugammadex on Renal Functions
- Conditions
- SugammadexNeostigmine
- Interventions
- First Posted Date
- 2023-10-13
- Last Posted Date
- 2023-10-13
- Lead Sponsor
- Menoufia University
- Target Recruit Count
- 64
- Registration Number
- NCT06081738
- Locations
- 🇪🇬
Menoufia University Hospitals, Shibīn Al Kawm, Menoufia, Egypt
The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery
- Conditions
- Emergence DeliriumStrabismusPediatric ALL
- Interventions
- First Posted Date
- 2023-09-13
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Konkuk University Medical Center
- Target Recruit Count
- 76
- Registration Number
- NCT06035757
- Locations
- 🇰🇷
Konkuk University Medical Center, Seoul, Seoul-T'ǔkpyǒlshi, Korea, Republic of
Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
- Conditions
- Critical IllnessNeuromuscular BlockadeNeurologic Findings
- Interventions
- First Posted Date
- 2023-08-15
- Last Posted Date
- 2024-06-24
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT05993390
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of
The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction
- Conditions
- IleusHernia, Ventral
- Interventions
- First Posted Date
- 2023-08-14
- Last Posted Date
- 2025-01-22
- Lead Sponsor
- Clayton Petro
- Target Recruit Count
- 184
- Registration Number
- NCT05985343
- Locations
- 🇺🇸
Cleveland Clinic Center for Abdominal Core Health, Cleveland, Ohio, United States
Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery
- Conditions
- Spine SurgeryReversal of Neuromuscular BlockadeUrinary Retention Postoperative
- Interventions
- First Posted Date
- 2023-06-02
- Last Posted Date
- 2023-09-29
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 118
- Registration Number
- NCT05887375
- Locations
- 🇺🇸
University Hospital, Columbia, Missouri, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.