Sugammadex
- Generic Name
- Sugammadex
- Brand Names
- Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
- Drug Type
- Small Molecule
- Chemical Formula
- C72H112O48S8
- CAS Number
- 343306-71-8
- Unique Ingredient Identifier
- 361LPM2T56
- Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
- Indication
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
- Associated Conditions
- Neuromuscular blockade caused by vecuronium bromide
The Role of Sugammadex in Posotoperative Urinary Retention in Patients Undergoing Pelvic Floor Reconstructive Procedures
- First Posted Date
- 2022-12-27
- Last Posted Date
- 2025-03-07
- Lead Sponsor
- West Virginia University
- Target Recruit Count
- 80
- Registration Number
- NCT05664633
- Locations
- 🇺🇸
West Virginia University Hospitals, Morgantown, West Virginia, United States
Sugammadex as Rescue Therapy
- First Posted Date
- 2022-12-22
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- Emory University
- Target Recruit Count
- 71
- Registration Number
- NCT05661409
- Locations
- 🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
- Conditions
- Neuromuscular Blockade
- Interventions
- First Posted Date
- 2022-09-19
- Last Posted Date
- 2025-02-10
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 50
- Registration Number
- NCT05545280
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
- Conditions
- Endobronchial MetastasesBronchoesophageal FistulaGeneral Anesthetic Drug Adverse Reaction
- Interventions
- First Posted Date
- 2022-07-21
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Zhejiang Cancer Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT05468671
- Locations
- 🇨🇳
Zhejiang Cancer Hospital, Hanzhou, China
Perioperative Respiratory Adverse events_sugammadex
- Conditions
- Respiratory Complication
- Interventions
- First Posted Date
- 2022-04-29
- Last Posted Date
- 2022-07-12
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 174
- Registration Number
- NCT05354466
- Locations
- 🇰🇷
Seoul national university hospital, Seoul, Korea, Republic of
Pharmacokinetics of Sugammadex in Reversal of Vecuronium-induced Neuromuscular Blockade in Patients During Laparoscopic Surgery
- First Posted Date
- 2022-04-14
- Last Posted Date
- 2022-04-14
- Lead Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
- Target Recruit Count
- 48
- Registration Number
- NCT05328778
- Locations
- 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China
Sugammadex and Smoker's Neuromuscular Block
- First Posted Date
- 2022-04-06
- Last Posted Date
- 2022-04-18
- Lead Sponsor
- Duzce University
- Target Recruit Count
- 40
- Registration Number
- NCT05313100
The POUR (Postoperative Urinary Retention) Study
- First Posted Date
- 2022-03-11
- Last Posted Date
- 2025-02-03
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 97
- Registration Number
- NCT05276804
- Locations
- 🇺🇸
Carolinas Medical Center, Charlotte, North Carolina, United States
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
- Conditions
- AppendicitisSurgery
- Interventions
- Drug: Neostigmine/Glycopyrrolate
- First Posted Date
- 2022-02-25
- Last Posted Date
- 2023-09-13
- Lead Sponsor
- Emory University
- Target Recruit Count
- 120
- Registration Number
- NCT05256901
- Locations
- 🇺🇸
Children's Healthcare of Altanta, Atlanta, Georgia, United States
Sugammadex Titration in Cardiac Surgery Patients
- Conditions
- Coronary Artery DiseaseValvular Heart DiseaseAorta DiseaseHeart Failure
- Interventions
- First Posted Date
- 2022-02-18
- Last Posted Date
- 2024-03-21
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 100
- Registration Number
- NCT05246397
- Locations
- 🇺🇸
University of Washington Medical Center, Seattle, Washington, United States
Drug Development Updates
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