Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Clinical Trials

Amoxicillin Susceptibility of Oral Streptococci After a 3-Day or a 7-Day Amoxicillin Therapy

Phase 4

Terminated

Conditions: Odontogenic Infection

Interventions: Drug: Amoxicillin

First Posted Date: 2008-10-01

Last Posted Date: 2008-10-01

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 81

Registration Number: NCT00764062

Locations: 🇫🇷
Assistance Publique - Hôpitaux de Paris, Paris, France

Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)

Phase 3

Completed

Conditions: Acute Rhinosinusitis

Interventions: Drug: mometasone furoate nasal spray (MFNS)
Drug: MFNS
Drug: Amoxicillin
Drug: Placebo

First Posted Date: 2008-09-11

Last Posted Date: 2024-08-15

Lead Sponsor: Organon and Co

Target Recruit Count: 981

Registration Number: NCT00751075

Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)

Phase 2

Completed

Conditions: Acute Rhinosinusitis

Interventions: Drug: Amoxicillin
Drug: Placebo
Drug: mometasone furoate nasal spray (MFNS)
Drug: MFNS

First Posted Date: 2008-09-11

Last Posted Date: 2024-08-15

Lead Sponsor: Organon and Co

Target Recruit Count: 981

Registration Number: NCT00750750

Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs

Not Applicable

Completed

Conditions: Malaria
Pneumonia

Interventions: Drug: Artemether-lumefantrine combination
Drug: amoxycillin
Drug: paracetamol
Device: malaria rapid diagnostic test, respiratory rate timer

First Posted Date: 2008-07-23

Last Posted Date: 2012-03-16

Lead Sponsor: Mbarara University of Science and Technology

Target Recruit Count: 6456

Registration Number: NCT00720811

Locations: 🇬🇭
Kassena Nankana Site, Kassana, Ghana
🇺🇬
Iganga Site, Iganga, Uganda
🇧🇫
Sapone Site, Sapone, Burkina Faso

and more 1 locations

Clarithromycin, Amoxicillin, and Metronidazole Based Regimens to Treat Helicobacter Pylori Infections in Colombia

Phase 3

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Clarithromycin, Metronidazole, Amoxicillin (+Omeprazole)
Drug: Clarithromycin, Amoxicillin, Omeprazole

First Posted Date: 2008-07-21

Last Posted Date: 2008-07-21

Lead Sponsor: University of North Texas Health Science Center

Target Recruit Count: 151

Registration Number: NCT00719420

Locations: 🇨🇴
Universidad del Valle, Cali, Colombia

Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization

Phase 4

Completed

Conditions: Periodontitis

Interventions: Drug: Placebo
Drug: Amoxicillin and Metronidazole

First Posted Date: 2008-06-30

Last Posted Date: 2015-03-03

Lead Sponsor: University Hospital Muenster

Target Recruit Count: 540

Registration Number: NCT00707369

Locations: 🇩🇪
Universitätsklinikum Carl Gustav Carus, Zentrum für Zahn-, Mund- und Kieferheilkunde, Dresden, Germany
🇩🇪
Medizinische Fakultät der Humboldt Universität Berlin (Charité), Berlin, Germany
🇩🇪
Zentrum der Zahn-, Mund- und Kieferheilkunde (Carolinum), Poliklinik für Parodontologie, Frankfurt, Germany

and more 5 locations