Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Clinical Trials

Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications

Phase 4

Completed

Conditions: Healthy

Interventions: Drug: cefdinir (Omnicef)
Drug: amoxicillin

First Posted Date: 2008-03-27

Last Posted Date: 2008-03-27

Lead Sponsor: Abbott

Target Recruit Count: 158

Registration Number: NCT00644891

Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis

Phase 3

Completed

Conditions: Acute Bacterial Sinusitis (ABS)

Interventions: Drug: Clarithromycin
Drug: Amoxicillin

First Posted Date: 2008-03-27

Last Posted Date: 2008-03-27

Lead Sponsor: Abbott

Target Recruit Count: 437

Registration Number: NCT00644553

A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children

Phase 3

Completed

Conditions: Tonsillitis

Interventions: Drug: amoxicillin
Drug: azithromycin SR

First Posted Date: 2008-03-26

Last Posted Date: 2011-05-17

Lead Sponsor: Pfizer

Target Recruit Count: 693

Registration Number: NCT00643149

Locations: 🇮🇳
Pfizer Investigational Site, Mumbai, Maharashtra, India

Middle Meatal Bacteriology During Acute Respiratory Infection in Children

Phase 4

Conditions: Acute Respiratory Infection
Sinusitis

Interventions: Drug: placebo
Drug: amoxicillin clavulanate acid

First Posted Date: 2007-10-18

Last Posted Date: 2007-10-19

Lead Sponsor: Oulu University Hospital

Target Recruit Count: 120

Registration Number: NCT00545961

Locations: 🇫🇮
Oulu University Hospital, Oulu, Finland
🇫🇮
Keski-pohjanmaan keskussairaala, Kokkola, Finland
🇫🇮
Etelä-Pohjanmaan Keskussairaala, Seinäjoki, Finland

Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children

Phase 4

Completed

Conditions: Otitis Media

Interventions: Drug: Amoxycillin
Drug: Placebo equivalent to amoxycillin

First Posted Date: 2007-10-04

Last Posted Date: 2010-05-24

Lead Sponsor: Menzies School of Health Research

Target Recruit Count: 126

Registration Number: NCT00539149

Locations: 🇦🇺
Menzies School of Health Research, Darwin, Northern Territory, Australia

Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease

Phase 4

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: Placebo
Drug: Amoxicillin and clavulanic acid

First Posted Date: 2007-07-03

Last Posted Date: 2012-03-13

Lead Sponsor: Catalan Society of Family Medicine

Target Recruit Count: 318

Registration Number: NCT00495586

Locations: 🇪🇸
Primary Healthcare Centre Molins de Rei, Molins de Rey, Catalonia, Spain
🇪🇸
Primary Healthcare Center Girona-4, Girona, Catalonia, Spain
🇪🇸
Primary Healthcare Center Les Muralles, Tarragona, Catalonia, Spain

and more 10 locations

Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura

Phase 4

Completed

Conditions: Chronic Idiopathic Thrombocytopenic Purpura
Helicobacter Pylori Infection

Interventions: Drug: lansoprazole, clarithromycin, amoxycillin

First Posted Date: 2007-04-30

Last Posted Date: 2013-05-03

Lead Sponsor: Mahidol University

Target Recruit Count: 26

Registration Number: NCT00467571

Locations: 🇹🇭
Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection

Phase 3

Conditions: Helicobacter Pylori Infection
Chronic Gastritis

First Posted Date: 2007-04-04

Last Posted Date: 2007-04-04

Lead Sponsor: Technische Universität Dresden

Target Recruit Count: 132

Registration Number: NCT00455806

Locations: 🇩🇪
Technical University of Munich, Medical Dept. II, Munich, Germany
🇩🇪
Med. Department, Jung-Stilling Krankenhaus, Siegen, Germany
🇩🇪
Med. Dept. I, Gastroenterology, University Hospital, Technical University of Dresden, Dresden, Germany

and more 4 locations