Amoxicillin
- Generic Name
- Amoxicillin
- Brand Names
- Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19N3O5S
- CAS Number
- 26787-78-0
- Unique Ingredient Identifier
- 9EM05410Q9
- Background
Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.
Amoxicillin was granted FDA approval on 18 January 1974.
- Indication
Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.
Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.
- Associated Conditions
- Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
- Associated Therapies
- -
Systemic Probiotics in the Periodontal Treatment
- First Posted Date
- 2018-11-07
- Last Posted Date
- 2020-01-13
- Lead Sponsor
- Belén Retamal-Valdes
- Target Recruit Count
- 176
- Registration Number
- NCT03733379
- Locations
- 🇧🇷
Federal University of Paraná, Curitiba, Paraná, Brazil
🇧🇷University of Guarulhos, Guarulhos, São Paulo, Brazil
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
- Conditions
- Interventions
- First Posted Date
- 2018-11-05
- Last Posted Date
- 2018-11-05
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 60
- Registration Number
- NCT03730766
- Locations
- 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori
- Conditions
- Interventions
- First Posted Date
- 2018-09-28
- Last Posted Date
- 2021-10-26
- Lead Sponsor
- Huazhong University of Science and Technology
- Target Recruit Count
- 360
- Registration Number
- NCT03688828
- Locations
- 🇨🇳
Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, China
Treatment of High-Risk Moderate Acute Malnutrition Using Expanded Admission Criteria
- Conditions
- Interventions
- First Posted Date
- 2018-08-27
- Last Posted Date
- 2020-09-01
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 1322
- Registration Number
- NCT03647150
- Locations
- 🇸🇱
Project Peanut Butter, Freetown, Sierra Leone
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
- First Posted Date
- 2018-08-01
- Last Posted Date
- 2019-08-30
- Lead Sponsor
- Xijing Hospital of Digestive Diseases
- Target Recruit Count
- 658
- Registration Number
- NCT03609892
- Locations
- 🇨🇳
Xijing Hosipital of Digestive Disease, Xi'an, Shaanxi, China
Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES)
- First Posted Date
- 2018-07-31
- Last Posted Date
- 2018-07-31
- Lead Sponsor
- The Leeds Teaching Hospitals NHS Trust
- Target Recruit Count
- 150
- Registration Number
- NCT03607734
- Locations
- 🇬🇧
Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Antibiotics Prior to Mini-screw Implant Insertion
- Conditions
- Interventions
- First Posted Date
- 2018-07-11
- Last Posted Date
- 2020-11-12
- Lead Sponsor
- St. Louis University
- Target Recruit Count
- 31
- Registration Number
- NCT03582605
- Locations
- 🇺🇸
Saint Louis University Center for Advanced Dental Education, Saint Louis, Missouri, United States
Azithromycin for Uncomplicated Severe Acute Malnutrition in Burkina Faso (Pilot)
- Conditions
- Interventions
- First Posted Date
- 2018-06-26
- Last Posted Date
- 2022-09-01
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 301
- Registration Number
- NCT03568643
- Locations
- 🇧🇫
Centre de Recherche en santé de nouna, Nouna, Boucle Du Mouhoun, Burkina Faso
Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection
- First Posted Date
- 2018-06-13
- Last Posted Date
- 2018-06-13
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 320
- Registration Number
- NCT03555526
- Locations
- 🇨🇳
Jyh-Ming Liou, Taipei, Taiwan, Taiwan-, Taiwan
Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study)
- Conditions
- Interventions
- First Posted Date
- 2018-06-04
- Last Posted Date
- 2021-04-28
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 1583
- Registration Number
- NCT03545373
- Locations
- 🇲🇼
University of Malawi College of Medicine, Blantyre, Southern, Malawi
Drug Development Updates
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