Zoledronic acid
- Generic Name
- Zoledronic acid
- Brand Names
- Aclasta, Reclast, Zometa, Zoledronic Acid Accord, Zoledronic acid Actavis, Zoledronic acid medac, Zoledronic acid Teva, Zoledronic Acid Hospira, Zoledronic acid Mylan
- Drug Type
- Small Molecule
- Chemical Formula
- C5H10N2O7P2
- CAS Number
- 118072-93-8
- Unique Ingredient Identifier
- 70HZ18PH24
- Background
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. Zoledronic acid ...
- Indication
Zoledronic acid is indicated to treat hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, osteoporosis in men and postmenopausal women, glucocorticoid induced osteoporosis, and Paget's disease of bone in men and women. Zoledronic acid is also indicated for the prevention of osteoporosis in post menopausal women and glucocorticoi...
- Associated Conditions
- Bone Metastases, Hypercalcemia of Malignancy, Multiple Myeloma (MM), Osteoporosis, Osteoporosis caused by Glucocorticoid Treatment, Paget's Disease of Bone, Paget’s Disease
- Associated Therapies
- Bone Mineral Density
4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases
- Conditions
- Interventions
- First Posted Date
- 2016-03-29
- Last Posted Date
- 2020-12-02
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 263
- Registration Number
- NCT02721433
- Locations
- 🇨🇦
The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study
- First Posted Date
- 2015-12-17
- Last Posted Date
- 2020-06-23
- Lead Sponsor
- Children's Hospital of Eastern Ontario
- Target Recruit Count
- 10
- Registration Number
- NCT02632916
- Locations
- 🇨🇦
Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2015-12-17
- Last Posted Date
- 2018-08-22
- Lead Sponsor
- Children's Hospital of Eastern Ontario
- Registration Number
- NCT02632903
- Locations
- 🇨🇦
Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Preventive Effects of Zoledronic Acid on Bone Metastasis in Patients With Stage IIIB and IV Lung Cancer
- First Posted Date
- 2015-12-04
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- Tang-Du Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT02622607
- Locations
- 🇨🇳
Department of Oncology，Tangdu Hospital，Fourth Millitary Medical University, XI'an, Shaanxi, China
Zoledronic Acid as Adjuvant Treatment of Triple-negative Breast Cancer
- First Posted Date
- 2015-11-03
- Last Posted Date
- 2015-11-03
- Lead Sponsor
- Chinese Academy of Medical Sciences
- Target Recruit Count
- 430
- Registration Number
- NCT02595138
Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II)
- Conditions
- Interventions
- First Posted Date
- 2015-10-28
- Last Posted Date
- 2023-09-26
- Lead Sponsor
- Susan L. Greenspan
- Target Recruit Count
- 310
- Registration Number
- NCT02589600
- Locations
- 🇺🇸
University of Pittsburgh Osteoporosis Prevention & Treatment Center, New Kensington, Pennsylvania, United States
Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone
- Conditions
- Interventions
- First Posted Date
- 2015-08-05
- Last Posted Date
- 2021-08-17
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 11
- Registration Number
- NCT02516423
- Locations
- 🇺🇸
Saint Luke's Mountain States Tumor Institute - Nampa, Nampa, Idaho, United States
🇺🇸Illinois CancerCare-Carthage, Carthage, Illinois, United States
🇺🇸Illinois CancerCare-Galesburg, Galesburg, Illinois, United States
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors
- Conditions
- Interventions
- First Posted Date
- 2015-07-24
- Last Posted Date
- 2024-11-06
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 22
- Registration Number
- NCT02508038
- Locations
- 🇺🇸
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation
- Conditions
- Interventions
- First Posted Date
- 2015-07-16
- Last Posted Date
- 2019-03-11
- Lead Sponsor
- 424 General Military Hospital
- Target Recruit Count
- 57
- Registration Number
- NCT02499237
- Locations
- 🇬🇷
251 Airforce & VA General Hospital, Athens, Greece
🇬🇷424 General Military Hospital, Thessaloniki, Greece
Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer
- Conditions
- Interventions
- First Posted Date
- 2015-06-24
- Last Posted Date
- 2019-01-16
- Lead Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Target Recruit Count
- 280
- Registration Number
- NCT02480634
Drug Development Updates
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