Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty

Not Applicable

Completed

Conditions: Femoral Neck Fractures

Interventions: Drug: Saline
Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2015-10-23

Last Posted Date: 2020-09-11

Lead Sponsor: St. Olavs Hospital

Target Recruit Count: 123

Registration Number: NCT02585011

Locations: 🇳🇴
Ortopedisk forskningssenter, St.Olavs Hospital, Trondheim, Norway

Magnesium Sulfate in Adductor Canal Blocks

Phase 4

Completed

Conditions: Knee Arthroplasty

Interventions: Other: Sham
Drug: Magnesium Sulfate
Drug: Ropivacaine

First Posted Date: 2015-10-21

Last Posted Date: 2020-11-13

Lead Sponsor: Queen's University

Target Recruit Count: 130

Registration Number: NCT02581683

Locations: 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada
🇨🇦
Hotel Dieu Hospital, Kingston, Ontario, Canada

The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty

Not Applicable

Conditions: Pain Management
Sedation
Peripheral Nerve Block
Total Knee Arthroplasty

Interventions: Procedure: peri-operative continuous femoral nerve block with light sedation
Procedure: post-operative continuous femoral nerve block
Drug: lidocaine
Device: ultrasound
Drug: saline
Device: insulated needle (Contiplex B Braun, Melsungen, Germany)
Drug: ropivacaine

First Posted Date: 2015-10-15

Last Posted Date: 2015-10-15

Lead Sponsor: Min Su

Target Recruit Count: 380

Registration Number: NCT02576015

Locations: 🇨🇳
The Department of Anesthesiology,the first Affiliated Hospital of Chongqing Medical University, Chonqqing, Chongqing, China

Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis

Phase 4

Completed

Conditions: Osteoarthritis

Interventions: Drug: Ropivacaine
Drug: Normal saline
Drug: Methylprednisolone

First Posted Date: 2015-10-15

Last Posted Date: 2017-08-21

Lead Sponsor: Mayo Clinic

Target Recruit Count: 29

Registration Number: NCT02576249

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Ropivacaine hydrochloride
Drug: Isotonic Saline
Drug: PCA-pump

First Posted Date: 2015-10-15

Last Posted Date: 2024-03-21

Lead Sponsor: Kai Henrik Wiborg Lange

Target Recruit Count: 40

Registration Number: NCT02576223

Locations: 🇩🇰
Holbæk Sygehus, Holbæk, Denmark
🇩🇰
Nordsjællands Hospital, Hillerød, Denmark

Liposomal Bupivacaine in Total Shoulder Arthroplasty

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Liposomal bupivacaine
Procedure: Inter-scalene nerve block
Drug: Ropivacaine

First Posted Date: 2015-10-07

Last Posted Date: 2016-10-13

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 57

Registration Number: NCT02570022

Locations: 🇺🇸
Henry Ford Health System, Detroit, Michigan, United States

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

Phase 4

Terminated

Conditions: Osteoarthritis, Knee

Interventions: Drug: 0.9% sodium chloride
Drug: Ropivacaine
Drug: Ketorolac
Drug: Clonidine
Drug: Epinephrine

First Posted Date: 2015-10-07

Last Posted Date: 2022-03-04

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 64

Registration Number: NCT02570503

Locations: 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery

Not Applicable

Completed

Conditions: Spinal Anesthesia

Interventions: Procedure: Intervertebral space
Drug: Ropivacaine

First Posted Date: 2015-10-01

Last Posted Date: 2018-03-01

Lead Sponsor: Shanghai 6th People's Hospital

Target Recruit Count: 60

Registration Number: NCT02565303

Locations: 🇨🇳
Shanghai Sixth People's Hospital, Shanghai, Shanghai, China

Location of Injection of Local Anesthetics in the Adductor Canal Block

Not Applicable

Completed

Conditions: Anesthesia
Adductor Canal Block

Interventions: Drug: lidocaine
Drug: ropivacaine

First Posted Date: 2015-09-18

Last Posted Date: 2019-02-27

Lead Sponsor: Women's College Hospital

Target Recruit Count: 108

Registration Number: NCT02554864

Locations: 🇨🇦
Women's College Hospital, Toronto, Ontario, Canada

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Phase 4

Completed

Conditions: Total Hip and Knee Arthroplasty

Interventions: Drug: Liposomal Bupivacaine
Drug: Ropivacaine
Drug: Bupivacaine
Drug: Clonidine
Drug: Epinephrine
Drug: Ketorolac

First Posted Date: 2015-09-07

Last Posted Date: 2019-10-18

Lead Sponsor: Kootenai Health

Target Recruit Count: 239

Registration Number: NCT02543801

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