Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

Phase 4

Completed

Conditions: The Duration of Motor Block May Vary Between 12-36 Hrs

Interventions: Drug: Bupivacaine
Drug: Ropivacaine

First Posted Date: 2011-01-10

Last Posted Date: 2017-04-06

Lead Sponsor: Northwestern University

Target Recruit Count: 142

Registration Number: NCT01272921

Locations: 🇺🇸
Northwestern University, Feingberg School of Medicine, Chicago, Illinois, United States

Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-

Phase 4

Completed

Conditions: Gastric Cancer

Interventions: Drug: Ropivacaine
Drug: morphine

First Posted Date: 2010-11-04

Last Posted Date: 2011-08-16

Lead Sponsor: Yonsei University

Target Recruit Count: 59

Registration Number: NCT01234272

Locations: 🇰🇷
Severance Hospital, Seoul, Korea, Republic of

Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Infiltrations

Not Applicable

Completed

Conditions: Hepatectomy
Pain
Metastasis

Interventions: Drug: Physiological serum
Drug: Ropivacaine

First Posted Date: 2010-09-03

Last Posted Date: 2015-04-21

Lead Sponsor: Centre Leon Berard

Target Recruit Count: 85

Registration Number: NCT01194843

Locations: 🇫🇷
Centre Léon Bérard, LYON Cedex 08, France

Bilateral Superficial Cervical Block for Thyroidectomy

Phase 4

Conditions: Cervical Pain

Interventions: Drug: 0.9% saline
Drug: Ropivacaine

First Posted Date: 2010-07-29

Last Posted Date: 2010-07-29

Lead Sponsor: Lifecenter Hospital

Target Recruit Count: 120

Registration Number: NCT01171885

Locations: 🇧🇷
Lifecenter Hospital, Belo Horizonte, Minas Gerais, Brazil

Comparison of Levobupivacaine and Ropivacaine for Femoral Neural Block

Phase 4

Terminated

Conditions: Pain
Arthroplasty, Replacement, Knee

Interventions: Drug: Levobupivacaine
Drug: Ropivacaine

First Posted Date: 2010-07-29

Last Posted Date: 2018-05-09

Lead Sponsor: NHS Tayside

Target Recruit Count: 14

Registration Number: NCT01172197

Postoperative Analgesia With Local Infiltration After Hip Fracture Of Intertrochanteric Type

Phase 4

Completed

Conditions: Hip Fracture of Intertrochanteric Type

Interventions: Drug: Ropivacaine
Drug: Saline

First Posted Date: 2010-05-07

Last Posted Date: 2011-03-16

Lead Sponsor: Odense University Hospital

Target Recruit Count: 74

Registration Number: NCT01119209

Locations: 🇩🇰
Odense University Hospital, Odense, DK, Denmark

Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Ropivacaine + Sufentanil
Drug: Ropivacaine

First Posted Date: 2010-03-09

Last Posted Date: 2015-03-19

Lead Sponsor: Hospices Civils de Lyon

Target Recruit Count: 90

Registration Number: NCT01082744

Locations: 🇫🇷
Hospices Civils de Lyon, Hopital Louis Pradel, Department of Anesthesiology, Bron, France

Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: intravenous lidocaine infusion
Drug: continuous ropivacaine preperitoneal infusion
Drug: NaCl
Drug: parenteral analgesia combining acetaminophen and morphine

First Posted Date: 2010-03-01

Last Posted Date: 2014-01-22

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 95

Registration Number: NCT01077752

Locations: 🇫🇷
Departement d'Anesthesie-Reanimation, Hopital Saint-Antoine, Paris, France

Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery

Phase 4

Completed

Conditions: Postoperative Pain
Surgery
Postoperative Complications

Interventions: Drug: ropivacaine
Drug: saline solution

First Posted Date: 2010-02-25

Last Posted Date: 2017-03-27

Lead Sponsor: Hospital Universitari de Bellvitge

Target Recruit Count: 225

Registration Number: NCT01075646

Locations: 🇪🇸
Anesthesiology Service of Univeritary Hospital of Bellvitge, Hospitalet . Barcelona, Barcelona, Spain

Topical Formulations of Liposomal Local Anesthetics

Phase 1

Completed

Conditions: Administration, Topical Drug
Administration, Topical
Anesthetic Drugs

Interventions: Drug: Ropivacaine

First Posted Date: 2010-01-22

Last Posted Date: 2010-01-22

Lead Sponsor: University of Campinas, Brazil

Target Recruit Count: 80

Registration Number: NCT01054547

Locations: 🇧🇷
Piracicaba Dental School, Piracicaba, Sao Paulo, Brazil

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