Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.
Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.
In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.
Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.
Millard Fillmore Suburban Hospital, Williamsville, New York, United States
Clinical Pharmacology of Miami, Hialeah, Florida, United States
West China Second University Hospital, Chengdu, Sichuan, China
Dow Institute of Radiology, Dow University of Health Sciences, Karachi, Sindh, Pakistan
Pamukkale University, Denizli, Turkey
Montefiore Medical Center, Bronx, New York, United States
Royal Alexandra Hospital, Edmonton, Alberta, Canada
Regina General Hospital, Regina, Saskatchewan, Canada
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom
St Georges University Hospital NHS Foundation Trust, London, United Kingdom
Lankenau Medical Center, Wynnewood, Pennsylvania, United States
Nationwide Children's Hospital, Columbus, Ohio, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.