Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Oral Paracetamol as Preemptive Analgesia for Labor Pain

Phase 3
Completed
Conditions
Interventions
First Posted Date
2013-03-26
Last Posted Date
2013-03-26
Lead Sponsor
Ain Shams University
Target Recruit Count
100
Registration Number
NCT01817829

Influence of Age on the Absorption and Metabolism of Cocoa Flavanols

First Posted Date
2013-02-12
Last Posted Date
2013-02-12
Lead Sponsor
University of Reading
Target Recruit Count
40
Registration Number
NCT01790009
Locations
🇬🇧

Department of Food and Nutritional Sciences, Reading, Berkshire, United Kingdom

Comparison of Acetaminophen and PRP Therapy for Knee OA

First Posted Date
2013-02-04
Last Posted Date
2015-11-20
Lead Sponsor
Hospital Universitario Dr. Jose E. Gonzalez
Target Recruit Count
543
Registration Number
NCT01782885
Locations
🇲🇽

Hospital Universitario Dr. José E. González, Monterrey, Nuevo León, Mexico

Pharmacokinetic Study to Compare Two Formulations of Paracetamol

Phase 1
Completed
Conditions
Interventions
First Posted Date
2013-01-14
Last Posted Date
2013-01-14
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
30
Registration Number
NCT01767428

CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen

First Posted Date
2013-01-08
Last Posted Date
2013-01-08
Lead Sponsor
Hospital Universitario Pedro Ernesto
Target Recruit Count
22
Registration Number
NCT01762891

Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants

First Posted Date
2012-12-24
Last Posted Date
2019-08-06
Lead Sponsor
Hillel Yaffe Medical Center
Target Recruit Count
19
Registration Number
NCT01755728
Locations
🇮🇱

Neonatal intensive care unit, Hillel Yaffe medical center, Hadera, Israel

The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period

Phase 4
Completed
Conditions
Interventions
First Posted Date
2012-12-03
Last Posted Date
2021-11-04
Lead Sponsor
NorthShore University HealthSystem
Target Recruit Count
140
Registration Number
NCT01739699
Locations
🇺🇸

NorthShore University HealthSystem, Evanston, Illinois, United States

Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-12-03
Last Posted Date
2017-12-26
Lead Sponsor
Vanderbilt University
Target Recruit Count
44
Registration Number
NCT01739361
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2012-11-29
Last Posted Date
2016-10-21
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
108
Registration Number
NCT01737593
Locations
🇺🇸

University of California, Los Angeles Medical Center, Los Angeles, California, United States

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