Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fed Condition

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Acetaminophen

First Posted Date: 2010-03-02

Last Posted Date: 2010-03-02

Lead Sponsor: Ranbaxy Laboratories Limited

Target Recruit Count: 26

Registration Number: NCT01079078

Locations: 🇮🇳
Clinical Pharmacology Unit, Majeedia Hospital (2nd Floor), New Delhi, India

The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children

Not Applicable

Conditions: Asthma

Interventions: Drug: paracetamol

First Posted Date: 2010-02-23

Last Posted Date: 2011-01-25

Lead Sponsor: Tel-Aviv Sourasky Medical Center

Target Recruit Count: 60

Registration Number: NCT01073748

Locations: 🇮🇱
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Indomethacin and Cardiac Bypass Surgery

Phase 4

Completed

Conditions: Hemorrhage

Interventions: Drug: Acetaminophen
Drug: Acetaminophen & Indomethacin
Drug: Indomethacin

First Posted Date: 2010-02-23

Last Posted Date: 2010-02-23

Lead Sponsor: Queen's University

Target Recruit Count: 82

Registration Number: NCT01073670

Locations: 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada

A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fasting Condition

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Acetaminophen

First Posted Date: 2010-02-23

Last Posted Date: 2010-02-23

Lead Sponsor: Ranbaxy Laboratories Limited

Target Recruit Count: 40

Registration Number: NCT01073709

Locations: 🇮🇳
Clinical Pharmacology Unit, Majeedia Hospital (2nd Floor), New Delhi, India

Paracetamol as Antipyretic and Analgesic Medication

Phase 4

Completed

Conditions: Fever
Analgesia

Interventions: Drug: Paracetamol

First Posted Date: 2010-02-18

Last Posted Date: 2010-02-18

Lead Sponsor: University of Athens

Target Recruit Count: 100

Registration Number: NCT01070732

Locations: 🇬🇷
2nd Department of Medicine, Sismanogleion General Hospital, Athens, Greece
🇬🇷
4th Department of Internal Medicine, ATTIKON University Hospital, Athens, Greece
🇬🇷
2nd Department of Surgery, G. Gennimatas General Hospital, Thessaloniki, Greece

Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia

Phase 2

Active, not recruiting

Conditions: Hairy Cell Leukemia

Interventions: Drug: Rituximab
Drug: Pentostatin
Drug: Bendamustine
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Epinephrine
Drug: Antihistamines
Drug: Corticosteroids
Drug: Bronchodilators
Other: Intravenous (IV) Saline

First Posted Date: 2010-02-01

Last Posted Date: 2024-05-01

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 69

Registration Number: NCT01059786

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Placebo Effect of Paracetamol in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteers

First Posted Date: 2010-01-21

Last Posted Date: 2012-01-30

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 40

Registration Number: NCT01053650

Locations: 🇫🇷
CHU Clermont-Ferrand, Clermont-Ferrand, France

Remifentanil Versus Paracetamol for Pain Treatment External Cephalic Versions.

Phase 3

Completed

Conditions: Breech Presentation
Pregnancy

Interventions: Drug: paracetamol
Drug: remifentanil

First Posted Date: 2010-01-13

Last Posted Date: 2011-04-14

Lead Sponsor: Basque Health Service

Target Recruit Count: 60

Registration Number: NCT01048398

Locations: 🇪🇸
Hospital Txagorritxu, Vitoria-Gasteiz, Alava, Spain

Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy

Phase 2

Completed

Conditions: Pain

Interventions: Drug: Placebo
Drug: Acetaminophen
Drug: Morphine Extended Release
Drug: Hydrocodone/Acetaminophen Extended Release

First Posted Date: 2009-12-24

Last Posted Date: 2014-04-08

Lead Sponsor: AbbVie (prior sponsor, Abbott)

Target Recruit Count: 250

Registration Number: NCT01038609

Locations: 🇺🇸
Site Reference ID/Investigator# 26302, Austin, Texas, United States
🇺🇸
Site Reference ID/Investigator# 26223, Peoria, Arizona, United States
🇺🇸
Site Reference ID/Investigator# 26303, San Marcos, Texas, United States

and more 1 locations

Safety and Effectiveness of Tramadex-OD After Knee Arthroscopy

Not Applicable

Conditions: Postoperative Pain

Interventions: Drug: extended-release tramadol
Drug: paracetamol

First Posted Date: 2009-12-02

Last Posted Date: 2010-02-02

Lead Sponsor: Shaare Zedek Medical Center

Target Recruit Count: 100

Registration Number: NCT01024348

Locations: 🇮🇱
Shaare Zedek Medical Center, Jerusalem, Israel

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