Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis

First Posted Date
2011-06-27
Last Posted Date
2017-08-01
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
351
Registration Number
NCT01382940
Locations
🇺🇸

Clnical & Translational Reseach Center for Alabama, PC, Tuscaloosa, Alabama, United States

🇺🇸

ArthroCare, Arthritis Care; and Research P.C., Gilbert, Arizona, United States

🇺🇸

Catalina Pointe Rheumatology, Tucson, Arizona, United States

and more 81 locations

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

First Posted Date
2011-06-06
Last Posted Date
2012-12-10
Lead Sponsor
Procare Riaya Hospital
Target Recruit Count
90
Registration Number
NCT01366313
Locations
🇸🇦

Procare Riaya Hospital, Al Khobar, Estern, Saudi Arabia

Inhibition of Lipid Peroxidation During Cardiac Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-06-06
Last Posted Date
2015-01-27
Lead Sponsor
Vanderbilt University
Target Recruit Count
67
Registration Number
NCT01366976
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies

First Posted Date
2011-04-11
Last Posted Date
2015-06-01
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
25
Registration Number
NCT01332578
Locations
🇬🇧

BIO-IMAGES Research Ltd., Glasgow, Scotland, United Kingdom

Sleep Disruption in New Mothers: An Intervention Trial

First Posted Date
2011-03-23
Last Posted Date
2012-02-29
Lead Sponsor
University of California, San Francisco
Target Recruit Count
152
Registration Number
NCT01321710
Locations
🇺🇸

University of California, San Francisco, California, United States

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-03-18
Last Posted Date
2011-04-01
Lead Sponsor
Pamukkale University
Target Recruit Count
73
Registration Number
NCT01318187
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

🇹🇷

Pamukkale University Hospital Emergency Department, Denizli, Turkey

Paracetamol for Cancer Pain

First Posted Date
2011-03-11
Last Posted Date
2011-03-11
Lead Sponsor
Haraldsplass Deaconess Hospital
Target Recruit Count
50
Registration Number
NCT01313247
Locations
🇳🇴

Haraldsplass Deaconess Hospital, Bergen, Norway

High Pain Intervention in Cesarean Sections

First Posted Date
2011-02-18
Last Posted Date
2018-09-10
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
69
Registration Number
NCT01298778
Locations
🇺🇸

Forsyth Medical Center-Sara Lee Center for Women's Health, Winston-Salem, North Carolina, United States

Paracetamol and Patent Ductus Arteriosus (PDA)

First Posted Date
2011-02-08
Last Posted Date
2012-12-19
Lead Sponsor
Shaare Zedek Medical Center
Target Recruit Count
80
Registration Number
NCT01291654
Locations
🇮🇱

Shaare Zedek Medical Center, Jerusalem, Israel

Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment

First Posted Date
2010-11-07
Last Posted Date
2019-05-10
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
850
Registration Number
NCT01235949
Locations
🇷🇴

GSK Investigational Site, Timisoara, Romania

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