Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

Pain in Patients With Dementia and Behavioural Disturbances

Phase 2

Completed

Conditions: Dementia
Pain
Agitation

Interventions: Drug: Paracetamol
Drug: Morphine
Drug: Buprenorphine plaster
Drug: Pregabalin

First Posted Date: 2009-11-30

Last Posted Date: 2011-08-10

Lead Sponsor: University of Bergen

Target Recruit Count: 352

Registration Number: NCT01021696

Locations: 🇳🇴
Fantoft Omsorgssenter, Bergen, Hordaland, Norway
🇳🇴
Solsletten Sykehjem, Bergen, Hordaland, Norway
🇳🇴
Odinsvei Nursing Home, Nesttun, Hordaland, Norway

and more 15 locations

Efficacy of Diclofenac Potassium Versus Acetaminophen in Febrile Children With Acute Upper Respiratory Tract Infections

Phase 4

Terminated

Conditions: Fever

Interventions: Drug: Diclofenac potassium
Drug: Acetaminophen

First Posted Date: 2009-11-25

Last Posted Date: 2012-11-19

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 2

Registration Number: NCT01019980

Locations: 🇻🇪
Ciudad Hospitalaria Enrique Tejera, Valencia, Estado Carabobo, Venezuela
🇻🇪
Hospital de niños "J. M. de los Rios", Distrito Metropolitano, Caracas, Venezuela

Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients

Phase 3

Completed

Conditions: Fever

Interventions: Drug: ibuprofen
Drug: acetaminophen

First Posted Date: 2009-10-27

Last Posted Date: 2016-11-06

Lead Sponsor: Cumberland Pharmaceuticals

Target Recruit Count: 118

Registration Number: NCT01002573

Locations: 🇺🇸
Staten Island University Hospital, Staten Island, New York, United States
🇺🇸
Texas Children's Hospital, Houston, Texas, United States
🇺🇸
Children's Memorial Hermann Hospital, Houston, Texas, United States

and more 14 locations

The Central Analgesic Effects of Paracetamol on Serotonergic Pathways

Not Applicable

Completed

Conditions: Analgesia

Interventions: Drug: Paracetamol
Drug: Placebo
Drug: Tropisetron

First Posted Date: 2009-09-02

Last Posted Date: 2013-01-29

Lead Sponsor: University Hospital, Basel, Switzerland

Target Recruit Count: 16

Registration Number: NCT00970450

Locations: 🇨🇭
University Hospital of Basel, Basel, Switzerland

Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates

Phase 2

Completed

Conditions: Pain
Fever

Interventions: Drug: paracetamol

First Posted Date: 2009-09-01

Last Posted Date: 2010-12-22

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 60

Registration Number: NCT00969176

Locations: 🇧🇪
University Hospitals Leuven, Leuven, Belgium

Adjuvant Analgesic Effects of Low Dose Tramadol/Acetaminophen Combination After Open Gynaecological Surgery

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: tramadol/acetaminophen
Drug: acetaminophen

First Posted Date: 2009-07-21

Last Posted Date: 2013-02-01

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 60

Registration Number: NCT00942565

Locations: 🇭🇰
Department of Anaesthesiology, The University of Hong Kong, Hong Kong, Hong Kong

The Effectiveness of Wet Cupping on Persistent Non-specific Low Back Pain

Not Applicable

Completed

Conditions: Low Back Pain

Interventions: Device: Wet Cupping
Drug: Acetaminophen

First Posted Date: 2009-06-22

Last Posted Date: 2010-01-05

Lead Sponsor: Korea Institute of Oriental Medicine

Target Recruit Count: 37

Registration Number: NCT00925951

Locations: 🇰🇷
Korea Institue of Oriental Medicine (KIOM), Doonsan Oriental Hospital of Daejeon University, Daejeon, Chungchong, Korea, Republic of