Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

VNRX-5133 Drug-Drug Interaction in Healthy Adult Volunteers

Phase 1

Completed

Conditions: Bacterial Infections

Interventions: Drug: VNRX-5133
Drug: Placebo
Drug: VNRX-5022
Drug: Metronidazole

First Posted Date: 2017-11-06

Last Posted Date: 2018-10-18

Lead Sponsor: Venatorx Pharmaceuticals, Inc.

Target Recruit Count: 42

Registration Number: NCT03332732

Locations: 🇺🇸
PRAHS, Lenexa, Kansas, United States

Drug Use Surveillance of Takecab for "Supplement to Helicobacter Pylori Eradication"

Completed

Conditions: Gastric/Duodenal Ulcer, Gastric MALT Lymphoma, Idiopathic Thrombocytopenic Purpura, or H. Pylori Gastritis, and Other

Interventions: Drug: Vonoprazan
Drug: Amoxicillin hydrate
Drug: Clarithromycin
Drug: Metronidazole

First Posted Date: 2017-07-17

Last Posted Date: 2019-03-22

Lead Sponsor: Takeda

Target Recruit Count: 560

Registration Number: NCT03219723

Locations: 🇯🇵
Takeda Selected Site, Tokyo, Japan

MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)

Phase 2

Completed

Conditions: Complicated Intra-Abdominal Infection

Interventions: Drug: Ceftolozane/Tazobactam
Drug: Meropenem
Drug: Placebo for Metronidazole
Drug: Metronidazole

First Posted Date: 2017-07-13

Last Posted Date: 2023-05-06

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 94

Registration Number: NCT03217136

Locations: 🇿🇦
Red Cross War Memorial Children's Hospital ( Site 1902), Cape Town, Western Cape, South Africa
🇲🇾
Universiti Kebangsaan Malaya Medical Centre ( Site 1101), Cheras, Johor, Malaysia
🇺🇸
Children's Hospital of Orange County ( Site 2502), Orange, California, United States

and more 47 locations

Prophylactic Antibiotics After Cesarean

Phase 1

Completed

Conditions: Surgical Site Infection

Interventions: Drug: Cephalexin
Drug: Placebo
Drug: Metronidazole

First Posted Date: 2017-06-14

Last Posted Date: 2023-08-16

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 321

Registration Number: NCT03187106

Locations: 🇺🇸
St. David's North Austin Medical Center, Austin, Texas, United States
🇺🇸
University of Texas Medical Branch John Sealy Hospital, Galveston, Texas, United States

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition

Phase 3

Conditions: Antibiotic Resistance
Malnutrition Severe
Antibiotic Toxicity

Interventions: Drug: Benzyl penicillin
Other: Placebo
Drug: Ceftriaxone
Drug: Metronidazole
Drug: Gentamicin

First Posted Date: 2017-06-02

Last Posted Date: 2020-05-19

Lead Sponsor: University of Oxford

Target Recruit Count: 2000

Registration Number: NCT03174236

Locations: 🇰🇪
Mbagathi Hospital, Nairobi, Kenya
🇰🇪
Coast General Hospital - Study site, Mombasa, Kenya
🇰🇪
Mbagathi District Hospital, Nairobi, Kenya

and more 4 locations

"Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children"

Not Applicable

Completed

Conditions: Overlap Syndrome
Autoimmune Hepatitis
Primary Sclerosing Cholangitis

Interventions: Drug: Metronidazole

First Posted Date: 2017-03-03

Last Posted Date: 2022-08-05

Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Target Recruit Count: 15

Registration Number: NCT03069976

Locations: 🇧🇪
Cliniques Universitaires Saint-Luc - Université Catholique de Louvain, Brussel, Bruxelles, Belgium

Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis

Phase 2

Completed

Conditions: Aggressive Periodontitis

Interventions: Procedure: Full-mouth ultrasonic debridement
Drug: Amoxicillin
Drug: Clarithromycin
Drug: Metronidazole

First Posted Date: 2016-11-21

Last Posted Date: 2021-12-28

Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho

Target Recruit Count: 46

Registration Number: NCT02969928

Locations: 🇧🇷
College of Dentistry - São José dos Campos, Sao Paulo State University, São José dos Campos, SP, Brazil

Treatment of Giardia Lamblia Infections in Children

Phase 4

Terminated

Conditions: GIARDIASIS

Interventions: Drug: Metronidazole
Drug: Tinidazole

First Posted Date: 2016-10-24

Last Posted Date: 2020-11-18

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 8

Registration Number: NCT02942485

Locations: 🇫🇮
Children's Hospital, HYKS, Helsinki, Finland

Tailored Versus Empiric Therapy for Helicobacter Pylori Treatment

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth Potassium Citrate
Drug: Amoxicillin
Drug: Metronidazole
Drug: Clarithromycin
Drug: Levofloxacin

First Posted Date: 2016-10-17

Last Posted Date: 2018-08-15

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 382

Registration Number: NCT02935010

Locations: 🇨🇳
Shanghai General Hospital, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai, China
🇨🇳
Zhongshan Hospital,Fudan University, Shanghai, Shanghai, China
🇨🇳
Shanghai Tenth People's Hospital, Tongji University, Shanghai, Shanghai, China

and more 2 locations

Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile

Phase 2

Completed

Conditions: Clostridium Difficile

Interventions: Drug: Vancomycin
Biological: Cultured human intestinal microbiota
Drug: Metronidazole

First Posted Date: 2016-08-05

Last Posted Date: 2019-01-09

Lead Sponsor: Per Hellström

Target Recruit Count: 60

Registration Number: NCT02857582

Locations: 🇸🇪
Gävle Hospital, Gävle, Gävleborg, Sweden

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy