Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
Instituto do Câncer do Estado de São Paulo - ICESP, São Paulo, Brazil
CHU Rennes - Hopital Pontchaillou, Rennes, France
Washington University School of Medicine, Saint Louis, Missouri, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
South Sacramento Cancer Center, Sacramento, California, United States
Kaiser Permanente-San Francisco, San Francisco, California, United States
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States
Research Site, Vinh, Vietnam
Providence St. Jude Medical Center ( Site 0106), Fullerton, California, United States
Ellis Fischel Cancer Center ( Site 0133), Columbia, Missouri, United States
Lake Regional Hospital-Cancer Center ( Site 0123), Osage Beach, Missouri, United States
Local Institution - 0066, Birmingham, Alabama, United States
Liverpool Hospital, Liverpool, New South Wales, Australia
The Ottawa Hospital - General Campus, Ottawa, Ontario, Canada
University of Alabama at Birmingham, Birmingham, Alabama, United States
Mayo Clinic, Phoenix, Arizona, United States
City of Hope, Duarte, California, United States
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