Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014, becoming the first approved therapy against PD-1. In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers.
Pembrolizumab is indicated for the following conditions:
For all approved adult indications, pembrolizumab may be used for an additional 6 weeks at 400mg weekly.
Research Administration Office, Los Angeles, California, United States
Ronald Reagan UCLA Medical Center, Drug Information Center, Los Angeles, California, United States
UCLA Hematology-Oncology Clinic, Los Angeles, California, United States
University of Connecticut Health Center Carole And Ray Neag Comprehensive Cancer Center, Farmington, Connecticut, United States
UC San Diego Moores Cancer Center, La Jolla, California, United States
Greater Baltimore Cancer Center, Baltimore, Maryland, United States
Brigham & Women's Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Medical University of Vienna, Vienna, Austria
Jules Bordet Institute, Brussels, Belgium
CHU Sart Tilman, Liège, Belgium
Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
Smilow Cancer Center at Yale New Haven Hospital, New Haven, Connecticut, United States
Highlands Oncology Group, Fayetteville, Arkansas, United States
Indiana Cancer Pavilion, Indianapolis, Indiana, United States
The West Clinic, Germantown, Tennessee, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Penn State Hershey Cancer Institue, Hershey, Pennsylvania, United States
Augusta University, Augusta, Georgia, United States
University of Tennessee Medical Center, Knoxville, Tennessee, United States
University of Kansas Cancer Center, Westwood, Kansas, United States
Oncology Specialists, Niles, Illinois, United States
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