Isoniazid

Generic Name: Isoniazid

Brand Names: Isonarif, Isotamine, Isotamine B, Rifamate, Rifater

Drug Type: Small Molecule

Chemical Formula: C_₆H_₇N_₃O

CAS Number: 54-85-3

Unique Ingredient Identifier: V83O1VOZ8L

Background: Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.

Indication: Isoniazid is used for the treatment of all forms of tuberculosis in which organisms are susceptible. It is also used in combination with rifampin and pyrazinamide.

Associated Conditions: Active Tuberculosis, Mycobacterium kansasii infection, Late phase Tuberculosis

Clinical Trials

NAT2 in Re-challenge of INH in Patients With Hepatitis

Phase 4

Conditions: Tuberculosis
Hepatotoxicity

Interventions: Drug: Isoniazid (Rifinah)

First Posted Date: 2008-08-06

Last Posted Date: 2012-12-27

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 100

Registration Number: NCT00728546

Locations: 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan

Rifapentine Plus Moxifloxacin for Treatment of Pulmonary Tuberculosis

Phase 2

Terminated

Conditions: Tuberculosis

Interventions: Drug: Rifapentine, Moxifloxacin, Pyrazinamide, Isoniazid
Drug: Isoniazid, Rifampin, Pyrazinamide, Ethambutol

First Posted Date: 2008-08-05

Last Posted Date: 2017-04-20

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 121

Registration Number: NCT00728507

Locations: 🇧🇷
Posto de Saude Albert Sabin, Rio de Janeiro, RJ, Brazil
🇧🇷
Hospital Universitario Clementio Fraga Filho, Rio de Janeiro, Brazil
🇧🇷
Centro de Referência Professor Hélio Fraga - ENSP - FIOCRUZ, Curicica, Rio de Janeiro, Brazil

Isoniazid Dose Adjustment According to NAT2 Genotype (IDANAT2)

Phase 3

Terminated

Conditions: Pulmonary Tuberculosis

Interventions: Drug: isoniazid

First Posted Date: 2007-12-12

Last Posted Date: 2011-02-28

Lead Sponsor: University of Cologne

Target Recruit Count: 900

Registration Number: NCT00571753

Locations: 🇩🇪
Helios Klinikum Emil von Behring GmbH, Berlin, Germany
🇧🇬
Specialized Hospital for Active Treatment of Pulmonary Diseases "Sveta Sofia", Sofia, Bulgaria
🇩🇪
Karl-Hansen-Klinik, Bad Lippspringe, Germany

and more 9 locations

High-Dose Isoniazid Adjuvant Therapy for Multidrug Resistant Tuberculosis

Phase 2

Completed

Conditions: Tuberculosis, Multidrug-Resistant

Interventions: Drug: Isoniazid
Drug: Placebo

First Posted Date: 2007-08-08

Last Posted Date: 2007-08-08

Lead Sponsor: GSVM Medical College

Target Recruit Count: 134

Registration Number: NCT00513396

Isoniazid Plus Antiretroviral Therapy to Prevent Tuberculosis in HIV-infected Persons

Not Applicable

Completed

Conditions: Tuberculosis
Latent Tuberculosis Infection
HIV Infections

Interventions: Drug: isoniazid
Drug: Placebo

First Posted Date: 2007-04-20

Last Posted Date: 2012-07-17

Lead Sponsor: University of Cape Town

Target Recruit Count: 1368

Registration Number: NCT00463086

Locations: 🇿🇦
Ubuntu Clinic,Site B Khayelitsha, Cape Town, Western Cape, South Africa

Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis

Phase 1

Completed

Conditions: Tuberculosis

Interventions: Drug: Moxifloxacin
Drug: Gatifloxacin
Drug: Levofloxacin
Drug: Isoniazid
Drug: Linezolid

First Posted Date: 2006-11-06

Last Posted Date: 2018-11-08

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 70

Registration Number: NCT00396084

Locations: 🇺🇸
San Francisco General Hospital - Pulmonary and Critical Care Medicine, San Francisco, California, United States
🇧🇷
Universidade Federal do Espirito Santo - Duke Hubert-Yeargan Center, Vitória, Espírito Santo, Brazil

Preventive Therapy for Tuberculosis in HIV Infected Persons

Phase 3

Completed

Conditions: Human Immunodeficiency Virus
Tuberculosis

Interventions: Drug: Isoniazid with Ethambutol

First Posted Date: 2006-07-13

Last Posted Date: 2024-05-22

Lead Sponsor: Tuberculosis Research Centre, India

Target Recruit Count: 683

Registration Number: NCT00351702

Locations: 🇮🇳
Tuberculosis Research Centre, Chennai, Tamilnadu, India

Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children

Phase 3

Completed

Conditions: Tuberculosis

Interventions: Drug: isoniazid
Other: placebo
Drug: Cotrimoxazole

First Posted Date: 2006-05-26

Last Posted Date: 2019-04-22

Lead Sponsor: University of Cape Town

Target Recruit Count: 450

Registration Number: NCT00330304

Locations: 🇿🇦
Red Cross Childrens Hospital, Cape Town, Western Cape, South Africa
🇿🇦
Tygerberg Hospital, Cape Town, Western Cape, South Africa

A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis

Phase 3

Completed

Conditions: Tuberculosis

First Posted Date: 2006-04-24

Last Posted Date: 2010-08-27

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 6400

Registration Number: NCT00317330

Locations: 🇧🇷
Municipal Health Department, Rio de Janeiro, Brazil

Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)

Phase 4

Completed

Conditions: Pulmonary Tuberculosis

Interventions: Drug: isoniazed
Drug: Isoniazid

First Posted Date: 2006-03-03

Last Posted Date: 2012-10-18

Lead Sponsor: Osaka University

Target Recruit Count: 172

Registration Number: NCT00298870

Locations: 🇯🇵
National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Osaka, Japan
🇯🇵
Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Osaka, Japan
🇯🇵
Osaka Hospital, Anti-Tuberculosis Association, Osaka Branch, Neyagawa, Osaka, Japan

and more 1 locations

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