Isoniazid

Generic Name: Isoniazid

Brand Names: Isonarif, Isotamine, Isotamine B, Rifamate, Rifater

Drug Type: Small Molecule

Chemical Formula: C_₆H_₇N_₃O

CAS Number: 54-85-3

Unique Ingredient Identifier: V83O1VOZ8L

Background: Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.

Indication: Isoniazid is used for the treatment of all forms of tuberculosis in which organisms are susceptible. It is also used in combination with rifampin and pyrazinamide.

Associated Conditions: Active Tuberculosis, Mycobacterium kansasii infection, Late phase Tuberculosis

Associated Therapies: -

Clinical Trials

Isoniazid Dose Adjustment According to NAT2 Genotype (IDANAT2)

Phase 3

Terminated

Conditions: Pulmonary Tuberculosis

Interventions: Drug: isoniazid

First Posted Date: 2007-12-12

Last Posted Date: 2011-02-28

Lead Sponsor: University of Cologne

Target Recruit Count: 900

Registration Number: NCT00571753

Locations: 🇩🇪
Helios Klinikum Emil von Behring GmbH, Berlin, Germany
🇧🇬
Specialized Hospital for Active Treatment of Pulmonary Diseases "Sveta Sofia", Sofia, Bulgaria
🇩🇪
Karl-Hansen-Klinik, Bad Lippspringe, Germany

and more 9 locations

High-Dose Isoniazid Adjuvant Therapy for Multidrug Resistant Tuberculosis

Phase 2

Completed

Conditions: Tuberculosis, Multidrug-Resistant

Interventions: Drug: Isoniazid
Drug: Placebo

First Posted Date: 2007-08-08

Last Posted Date: 2007-08-08

Lead Sponsor: GSVM Medical College

Target Recruit Count: 134

Registration Number: NCT00513396

Isoniazid Plus Antiretroviral Therapy to Prevent Tuberculosis in HIV-infected Persons

Not Applicable

Completed

Conditions: Tuberculosis
Latent Tuberculosis Infection
HIV Infections

Interventions: Drug: isoniazid
Drug: Placebo

First Posted Date: 2007-04-20

Last Posted Date: 2012-07-17

Lead Sponsor: University of Cape Town

Target Recruit Count: 1368

Registration Number: NCT00463086

Locations: 🇿🇦
Ubuntu Clinic,Site B Khayelitsha, Cape Town, Western Cape, South Africa

Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis

Phase 1

Completed

Conditions: Tuberculosis

Interventions: Drug: Moxifloxacin
Drug: Gatifloxacin
Drug: Levofloxacin
Drug: Isoniazid
Drug: Linezolid

First Posted Date: 2006-11-06

Last Posted Date: 2018-11-08

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 70

Registration Number: NCT00396084

Locations: 🇺🇸
San Francisco General Hospital - Pulmonary and Critical Care Medicine, San Francisco, California, United States
🇧🇷
Universidade Federal do Espirito Santo - Duke Hubert-Yeargan Center, Vitória, Espírito Santo, Brazil

Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children

Phase 3

Completed

Conditions: Tuberculosis

Interventions: Drug: isoniazid
Other: placebo
Drug: Cotrimoxazole

First Posted Date: 2006-05-26

Last Posted Date: 2019-04-22

Lead Sponsor: University of Cape Town

Target Recruit Count: 450

Registration Number: NCT00330304

Locations: 🇿🇦
Red Cross Childrens Hospital, Cape Town, Western Cape, South Africa
🇿🇦
Tygerberg Hospital, Cape Town, Western Cape, South Africa

A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis

Phase 3

Completed

Conditions: Tuberculosis

First Posted Date: 2006-04-24

Last Posted Date: 2010-08-27

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 6400

Registration Number: NCT00317330

Locations: 🇧🇷
Municipal Health Department, Rio de Janeiro, Brazil

Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)

Phase 4

Completed

Conditions: Pulmonary Tuberculosis

Interventions: Drug: isoniazed
Drug: Isoniazid

First Posted Date: 2006-03-03

Last Posted Date: 2012-10-18

Lead Sponsor: Osaka University

Target Recruit Count: 172

Registration Number: NCT00298870

Locations: 🇯🇵
National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Osaka, Japan
🇯🇵
Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Osaka, Japan
🇯🇵
Osaka Hospital, Anti-Tuberculosis Association, Osaka Branch, Neyagawa, Osaka, Japan

and more 1 locations

Treatment of Latent Tuberculosis Infection With Isoniazid

Phase 4

Completed

Conditions: Tuberculosis

Interventions: Drug: isoniazid

First Posted Date: 2006-02-17

Last Posted Date: 2010-05-26

Lead Sponsor: Instituto Nacional de Salud Publica, Mexico

Target Recruit Count: 200

Registration Number: NCT00293228

Locations: 🇲🇽
Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico

Rifampin Versus Isoniazid for the Treatment of Latent Tuberculosis Infection in Children (P4v9)

Phase 3

Completed

Conditions: Latent Tuberculosis Infection

Interventions: Drug: Rifampin
Drug: Isoniazid

First Posted Date: 2005-09-15

Last Posted Date: 2017-12-19

Lead Sponsor: McGill University

Target Recruit Count: 844

Registration Number: NCT00170209

Locations: 🇧🇷
Universidade Gama Filho, Centro de Ciências Biológicas e da Saúde, Rio de Janeiro, Brazil
🇮🇩
Health Research Unit, Faculty of Medicine, Bandung, West Java, Indonesia
🇧🇯
Centre de Pneumophthysiologie, Cotonou, Benin

and more 6 locations

Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in Botswana

Phase 4

Completed

Conditions: HIV Infections
Tuberculosis

Interventions: Drug: Isoniazid

First Posted Date: 2005-09-14

Last Posted Date: 2014-02-06

Lead Sponsor: Centers for Disease Control and Prevention

Target Recruit Count: 2000

Registration Number: NCT00164281

Locations: 🇧🇼
Gaborone and Francistown Health Clinics, Gaborone and Francistown, Botswana

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