Naloxone
- Generic Name
- Naloxone
- Brand Names
- Kloxxado, Narcan, Suboxone, Targin, Targiniq, Zimhi, Zubsolv, Nyxoid
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO4
- CAS Number
- 465-65-6
- Unique Ingredient Identifier
- 36B82AMQ7N
- Background
Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other d...
- Indication
Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present. Intramuscular, intravenous, and subcutaneous injections are indicated for complete or partial reversal of opioid depression, diagnosis of known or s...
- Associated Conditions
- Opioid Dependence, Opioid Overdose, Pruritus, Respiratory Depression, Septic Shock, Severe Pain, Moderate Pain, Suspected Opioid Overdose
- Associated Therapies
- Emergency Care
Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers
- First Posted Date
- 2015-10-08
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 30
- Registration Number
- NCT02572089
- Locations
- 🇺🇸
Vince Associates Clinical Research, Overland Park, Kansas, United States
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
- Conditions
- Interventions
- First Posted Date
- 2015-06-11
- Last Posted Date
- 2020-09-23
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 117
- Registration Number
- NCT02469077
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
🇺🇸Rush University, Chicago, Illinois, United States
Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
- Conditions
- Interventions
- First Posted Date
- 2015-04-14
- Last Posted Date
- 2016-02-22
- Lead Sponsor
- Kyungpook National University Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT02416115
Efficacy of Naloxone in Reducing Postictal Central Respiratory Dysfunction in Patients with Epilepsy
- First Posted Date
- 2015-01-06
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Hospices Civils de Lyon
- Target Recruit Count
- 485
- Registration Number
- NCT02332447
- Locations
- 🇫🇷
Service de Neurologie Fonctionnelle et d'Epileptologie et Institut des Epilepsies Hôpital Neurologique, Lyon, France
To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
- Conditions
- Interventions
- First Posted Date
- 2014-12-22
- Last Posted Date
- 2016-11-04
- Lead Sponsor
- Mundipharma Research GmbH & Co KG
- Target Recruit Count
- 155
- Registration Number
- NCT02321397
Feasibility Study of Oral Naloxone for Treatment of Methadone-induced Constipation
- First Posted Date
- 2014-05-13
- Last Posted Date
- 2015-06-24
- Lead Sponsor
- Centre for Addiction and Mental Health
- Target Recruit Count
- 20
- Registration Number
- NCT02137213
- Locations
- 🇨🇦
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Drug Interaction & Methadone & Buprenorphine
- Conditions
- Interventions
- First Posted Date
- 2014-01-27
- Last Posted Date
- 2014-06-17
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 32
- Registration Number
- NCT02045693
- Locations
- 🇺🇸
Cri Lifetree, Philadelphia, Pennsylvania, United States
🇺🇸Anaheim Clinical Trials Llc, Anaheim, California, United States
🇺🇸Lifetree Clinical Research, Salt Lake City, Utah, United States
Neuropeptides in Human Reproduction
- Conditions
- Interventions
- First Posted Date
- 2013-09-30
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 61
- Registration Number
- NCT01952782
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
The Relationships Between the Noradrenergic, Opioid and Pain System
- Conditions
- Interventions
- First Posted Date
- 2013-05-10
- Last Posted Date
- 2017-10-04
- Lead Sponsor
- Rambam Health Care Campus
- Registration Number
- NCT01851486
- Locations
- 🇮🇱
Rambam Health Care Campus, Haifa, Israel
Oral Oxycodone After Major Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-03-22
- Last Posted Date
- 2014-03-26
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 50
- Registration Number
- NCT01816581
- Locations
- 🇦🇹
Medical University Vienna, Vienna, Austria
Drug Development Updates
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