Exenatide

Generic Name: Exenatide

Brand Names: Bydureon, Byetta

Drug Type: Biotech

CAS Number: 141758-74-9

Unique Ingredient Identifier: 9P1872D4OL

Background: Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulations. Bydureon, the brand name product of extended-release exenatide in an injectable suspension, was discontinued in 2021. Bydureon BCise, an auto-injector extended-release formulation, remains available.

Indication: Exenatide is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. An extended-release formulation is available which is indicated in patients ≥10 years old, while the immediate-acting formulation is approved only for adult patients.

Associated Conditions: Type 2 Diabetes Mellitus

Clinical Trials

A Study of the Safety and Effectiveness of LY3053102 in Participants With Type 2 Diabetes

Phase 1

Terminated

Conditions: Type 2 Diabetes Mellitus

Interventions: Drug: Exenatide ER
Drug: Placebo
Drug: LY3053102
Drug: Metformin

First Posted Date: 2013-12-25

Last Posted Date: 2019-10-08

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 60

Registration Number: NCT02020616

Locations: 🇺🇸
Orange County Research Center, Orange, California, United States
🇺🇸
Compass Research, Orlando, Florida, United States
🇺🇸
Clinilabs, Inc (New York), New York, New York, United States

and more 2 locations

Trial of Exenatide for Parkinson's Disease

Phase 2

Completed

Conditions: Parkinson's Disease

Interventions: Other: Placebo
Drug: Exenatide

First Posted Date: 2013-10-29

Last Posted Date: 2016-11-17

Lead Sponsor: University College, London

Target Recruit Count: 60

Registration Number: NCT01971242

Locations: 🇬🇧
National Hospital for Neurology & Neurosurgery (part of UCLH NHS Trust), London, United Kingdom

Exenatide for Stress Hyperglycemia

Phase 2

Completed

Conditions: Stress Hyperglycemia

Interventions: Drug: Insulin
Drug: Exenatide

First Posted Date: 2013-10-25

Last Posted Date: 2017-10-06

Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Target Recruit Count: 110

Registration Number: NCT01969149

Locations: 🇫🇷
Post operative intensive care unit of the cardiac surgery department, Besançon, France

Effect of Exenatide on Liver and Heart Fat and Inflammation

Phase 4

Completed

Conditions: Type 2 Diabetes Mellitus

Interventions: Drug: Exenatide
Drug: Glipizide

First Posted Date: 2013-09-26

Last Posted Date: 2016-05-16

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 24

Registration Number: NCT01951651

Locations: 🇺🇸
Baylor College of Medicine, Houston, Texas, United States

Exenatide for Myocardial Protection During Reperfusion Study

Phase 2

Conditions: Myocardial Infarction

Interventions: Drug: Placebo
Drug: Exenatide

First Posted Date: 2013-09-10

Last Posted Date: 2016-08-05

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 198

Registration Number: NCT01938235

Locations: 🇨🇦
Institut universitaire de cardiologie et de pneumologie de Quebec (Hopital Laval), Quebec City, Quebec, Canada
🇨🇦
Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
🇨🇦
Southlake Regional Health Centre, Newmarket, Ontario, Canada

and more 7 locations

A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I Diabetes

Phase 2

Completed

Conditions: Type I Diabetes

Interventions: Drug: Placebo
Drug: Exenatide (Bydureon®)

First Posted Date: 2013-08-23

Last Posted Date: 2020-03-19

Lead Sponsor: Yale University

Target Recruit Count: 79

Registration Number: NCT01928329

Locations: 🇺🇸
Yale University, New Haven, Connecticut, United States
🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
🇺🇸
University of Chicago, Chicago, Illinois, United States

and more 5 locations