Phenobarbital
- Generic Name
- Phenobarbital
- Brand Names
- Donnatal, Luminal, Phenobarb, Phenohytro, Sezaby
- Drug Type
- Small Molecule
- Chemical Formula
- C12H12N2O3
- CAS Number
- 50-06-6
- Unique Ingredient Identifier
- YQE403BP4D
- Background
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
- Indication
For the treatment of all types of seizures except absence seizures.
- Associated Conditions
- Alcohol Withdrawal Syndrome, Anxiety, Febrile Convulsions, Hyperbilirubinemia, Insomnia, Menopausal Symptoms, Partial-Onset Seizures, Seizures, Generalized, Withdrawal Symptoms
- Associated Therapies
- Sedation
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
Phase 3
Completed
- Conditions
- Interventions
- First Posted Date
- 2001-02-05
- Last Posted Date
- 2019-03-22
- Lead Sponsor
- NICHD Neonatal Research Network
- Target Recruit Count
- 610
- Registration Number
- NCT00009620
- Locations
- 🇺🇸
Yale University, New Haven, Connecticut, United States
🇺🇸George Washington University, Washington, District of Columbia, United States
🇺🇸University of New Mexico, Albuquerque, New Mexico, United States
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