Phenobarbital
- Generic Name
- Phenobarbital
- Brand Names
- Donnatal, Luminal, Phenobarb, Phenohytro, Sezaby
- Drug Type
- Small Molecule
- Chemical Formula
- C12H12N2O3
- CAS Number
- 50-06-6
- Unique Ingredient Identifier
- YQE403BP4D
- Background
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
- Indication
For the treatment of all types of seizures except absence seizures.
- Associated Conditions
- Alcohol Withdrawal Syndrome, Anxiety, Febrile Convulsions, Hyperbilirubinemia, Insomnia, Menopausal Symptoms, Partial-Onset Seizures, Seizures, Generalized, Withdrawal Symptoms
- Associated Therapies
- Sedation
Study to Evaluate Phenobarbital Sodium Injection for the Treatment of Neonatal Seizures
- First Posted Date
- 2018-07-26
- Last Posted Date
- 2019-08-28
- Lead Sponsor
- PharPoint Research, Inc.
- Registration Number
- NCT03602118
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
- Conditions
- Alcohol Withdrawal SeizuresAlcohol Withdrawal DeliriumAlcohol Withdrawal
- Interventions
- Drug: Inactive placebo
- First Posted Date
- 2018-07-13
- Last Posted Date
- 2023-11-02
- Lead Sponsor
- Unity Health Toronto
- Target Recruit Count
- 8
- Registration Number
- NCT03586089
- Locations
- 🇨🇦
St. Michael's Hospital, Toronto, Ontario, Canada
Population Pharmacokinetics of Antiepileptic in Pediatrics
- Conditions
- Epilepsy
- Interventions
- Biological: brivaracétamBiological: pregabalineOther: genetic polymorphisms
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 1000
- Registration Number
- NCT03196466
- Locations
- 🇫🇷
AP-HP Cochin, Paris, France
Efficacy of Levetiracetam in Control of Neonatal Seizures Guided by an EEG
- First Posted Date
- 2017-04-11
- Last Posted Date
- 2017-04-11
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 40
- Registration Number
- NCT03107507
- Locations
- 🇪🇬
Cairo University Children's Hospital (Abulreesh), Cairo Governorate, Egypt
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus
- Conditions
- Generalized Convulsive Status Epilepticus
- Interventions
- First Posted Date
- 2017-01-20
- Last Posted Date
- 2019-07-09
- Lead Sponsor
- Xuanwu Hospital, Beijing
- Target Recruit Count
- 120
- Registration Number
- NCT03025906
- Locations
- 🇨🇳
Xuanwu Hospital, Beijing, Beijing, China
🇨🇳Xijing Hospital, Shanxi, Xi'an, China
🇨🇳Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China
How to Treat Opiate Withdrawal in Neonates
- Conditions
- Neonatal Abstinence Syndrome
- Interventions
- First Posted Date
- 2016-06-23
- Last Posted Date
- 2020-01-07
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 120
- Registration Number
- NCT02810782
Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus
- Conditions
- Status EpilepticusEpilepsy
- Interventions
- First Posted Date
- 2016-04-04
- Last Posted Date
- 2017-08-29
- Lead Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
- Registration Number
- NCT02726867
- Locations
- 🇺🇸
MidAtlantic Epilepsy and Sleep Center, Bethesda, Maryland, United States
Levetiracetam Treatment of Neonatal Seizures
- Conditions
- Neonatal Seizures
- Interventions
- First Posted Date
- 2015-09-15
- Last Posted Date
- 2023-12-29
- Lead Sponsor
- Children's Hospital of Fudan University
- Target Recruit Count
- 60
- Registration Number
- NCT02550028
- Locations
- 🇨🇳
Children Hospital of Fudan University, Shanghai, Shanghai, China
Pharmacovigilance in Gerontopsychiatric Patients
- Conditions
- DementiaDepressionSchizophreniaPsychosomatic DisordersAnxiety Disorders
- Interventions
- First Posted Date
- 2015-03-02
- Last Posted Date
- 2018-02-28
- Lead Sponsor
- Hannover Medical School
- Target Recruit Count
- 407
- Registration Number
- NCT02374567
- Locations
- 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪Hannover Medical School, Hannover, Germany
Improving Outcomes in Neonatal Abstinence Syndrome
- Conditions
- Neonatal Abstinence SyndromeNeonatal Opioid Withdrawal
- Interventions
- First Posted Date
- 2013-10-09
- Last Posted Date
- 2019-10-15
- Lead Sponsor
- Tufts Medical Center
- Target Recruit Count
- 117
- Registration Number
- NCT01958476
- Locations
- 🇺🇸
Baystate Medical Center, Springfield, Massachusetts, United States
🇺🇸Shands Jacksonville Medical Center, Jacksonville, Florida, United States
🇺🇸Boston Medical Center, Boston, Massachusetts, United States
Drug Development Updates
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