Phenobarbital

Generic Name
Phenobarbital
Brand Names
Donnatal, Luminal, Phenobarb, Phenohytro, Sezaby
Drug Type
Small Molecule
Chemical Formula
C12H12N2O3
CAS Number
50-06-6
Unique Ingredient Identifier
YQE403BP4D
Background

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Indication

For the treatment of all types of seizures except absence seizures.

Associated Conditions
Alcohol Withdrawal Syndrome, Anxiety, Febrile Convulsions, Hyperbilirubinemia, Insomnia, Menopausal Symptoms, Partial-Onset Seizures, Seizures, Generalized, Withdrawal Symptoms
Associated Therapies
Sedation
Clinical Trials
Related News

Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus

First Posted Date
2016-04-04
Last Posted Date
2017-08-29
Lead Sponsor
Mid-Atlantic Epilepsy and Sleep Center, LLC
Registration Number
NCT02726867
Locations
🇺🇸

MidAtlantic Epilepsy and Sleep Center, Bethesda, Maryland, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Improving Outcomes in Neonatal Abstinence Syndrome

First Posted Date
2013-10-09
Last Posted Date
2019-10-15
Lead Sponsor
Tufts Medical Center
Target Recruit Count
117
Registration Number
NCT01958476
Locations
🇺🇸

Baystate Medical Center, Springfield, Massachusetts, United States

🇺🇸

Shands Jacksonville Medical Center, Jacksonville, Florida, United States

🇺🇸

Boston Medical Center, Boston, Massachusetts, United States

and more 5 locations

Evaluation Phenobarbital as Adjunctive Therapy in Participants With Partial Onset Seizures

Phase 3
Completed
Conditions
Epilepsy
Interventions
Drug: Placebo tablet
Drug: Phenobarbital
First Posted Date
2011-01-27
Last Posted Date
2017-11-14
Lead Sponsor
West-Ward Pharmaceutical
Target Recruit Count
314
Registration Number
NCT01284556
Locations
🇵🇷

Centro Neurodiagnostico, Rio Piedras, Puerto Rico

🇵🇷

Hospital Del Maestro, San Juan, Puerto Rico

🇺🇸

Bluegrass Epilepsy Research, Lexington, Kentucky, United States

and more 1 locations

Effect of CYP2C9/CYP2C19 Polymorphism on Pharmacokinetics of Phenobarbital in Korean Neonatal Seizure Patients.

Not Applicable
Completed
Conditions
Neonatal Seizure
First Posted Date
2010-10-20
Last Posted Date
2012-01-31
Lead Sponsor
Yonsei University
Target Recruit Count
52
Registration Number
NCT01224457

Clonidine for Neonatal Abstinence Syndrome Study

Not Applicable
Terminated
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Clonidine
Drug: Phenobarbital
First Posted Date
2010-08-05
Last Posted Date
2014-01-06
Lead Sponsor
Baystate Medical Center
Target Recruit Count
68
Registration Number
NCT01175668
Locations
🇺🇸

NICU @ Baystate Children's Hospital, Springfield, Massachusetts, United States

Prophylactic Phenobarbital After Neonatal Seizures

Phase 4
Terminated
Conditions
Neonatal Seizures
Interventions
Drug: placebo
Drug: phenobarbital
First Posted Date
2010-03-18
Last Posted Date
2016-02-03
Lead Sponsor
University of Rochester
Target Recruit Count
13
Registration Number
NCT01089504
Locations
🇺🇸

Women & Infants Hospital of Rhode Island, Providence, Rhode Island, United States

🇺🇸

Johns Hopkins University, Baltimore, Maryland, United States

🇺🇸

Akron Children's Hospital, Akron, Ohio, United States

and more 15 locations

Study of Phenobarbital Inhibition of Catamenial Epilepsy

Not Applicable
Withdrawn
Conditions
Epilepsy
Interventions
Other: Placebo
Drug: Phenobarbital
First Posted Date
2007-09-17
Last Posted Date
2014-12-10
Lead Sponsor
University of Toledo Health Science Campus
Registration Number
NCT00530413
Locations
🇺🇸

University of Toledo, Health Science Campus, Toledo, Ohio, United States

Prediction of Childhood Epilepsy Outcome in Bangladesh

Not Applicable
Completed
Conditions
Epilepsy
First Posted Date
2006-09-28
Last Posted Date
2006-12-25
Lead Sponsor
Institute of Child Health
Target Recruit Count
92
Registration Number
NCT00381537
Locations
🇬🇧

Institute of Child Health, London, United Kingdom

🇧🇩

Children's Hospital Dhaka (Shishu) Bangladesh., Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh

Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma

First Posted Date
2004-03-26
Last Posted Date
2013-02-05
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
3
Registration Number
NCT00002759
Locations
🇺🇸

University of Chicago Cancer Research Center, Chicago, Illinois, United States

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