Pentamidine
- Generic Name
- Pentamidine
- Brand Names
- Nebupent, Pentam
- Drug Type
- Small Molecule
- Chemical Formula
- C19H24N4O2
- CAS Number
- 100-33-4
- Unique Ingredient Identifier
- 673LC5J4LQ
- Background
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
- Indication
For the treatment of pneumonia due to Pneumocystis carinii.
- Associated Conditions
- Pneumocystis Jirovecii Pneumonia, Trypanosomiasis
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 45
- Registration Number
- NCT00000722
- Locations
- ๐บ๐ธ
SUNY - Stony Brook, Stony Brook, New York, United States
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 322
- Registration Number
- NCT00000727
- Locations
- ๐บ๐ธ
University of Washington AIDS CRS, Seattle, Washington, United States
๐บ๐ธBmc Actg Crs, Boston, Massachusetts, United States
๐บ๐ธIndiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 364
- Registration Number
- NCT00001013
- Locations
- ๐บ๐ธ
Tulane Univ School of Medicine, New Orleans, Louisiana, United States
๐บ๐ธCharity Hosp / Tulane Univ Med School, New Orleans, Louisiana, United States
๐บ๐ธSUNY / State Univ of New York, Syracuse, New York, United States
Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 240
- Registration Number
- NCT00000730
- Locations
- ๐บ๐ธ
Julio Arroyo, West Columbia, South Carolina, United States
An Open Label Study to Evaluate the Long-Term Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002030
- Locations
- ๐บ๐ธ
Fisons Corp, Rochester, New York, United States
A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Registration Number
- NCT00001996
- Locations
- ๐บ๐ธ
UCI Med Ctr, Orange, California, United States
๐บ๐ธCedars Sinai Med Ctr, Los Angeles, California, United States
๐บ๐ธAIDS Community Research Consortium, Redwood City, California, United States
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002055
- Locations
- ๐บ๐ธ
Northwestern Univ Med School, Chicago, Illinois, United States
๐บ๐ธBeth Israel Deaconess - West Campus, Boston, Massachusetts, United States
๐บ๐ธGeorgetown Univ, Washington, District of Columbia, United States
A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002053
- Locations
- ๐บ๐ธ
Fisons Corp, Rochester, New York, United States
A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Fisons
- Registration Number
- NCT00002054
- Locations
- ๐บ๐ธ
Fisons Corp, Rochester, New York, United States
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
- Conditions
- HIV InfectionsPneumonia, Pneumocystis Carinii
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- LyphoMed
- Registration Number
- NCT00002056
- Locations
- ๐บ๐ธ
LyphoMed Inc, Rosemont, Illinois, United States
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