Tenecteplase
- Generic Name
- Tenecteplase
- Brand Names
- Metalyse, Tnkase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 191588-94-0
- Unique Ingredient Identifier
- WGD229O42W
- Background
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease doma...
- Indication
用于溶栓治疗。
- Associated Conditions
- Cardiovascular Mortality
- Associated Therapies
- -
Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke
- Conditions
- Interventions
- First Posted Date
- 2024-10-26
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- Xuanwu Hospital, Beijing
- Target Recruit Count
- 850
- Registration Number
- NCT06658197
- Locations
- 🇨🇳
Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
- Conditions
- Interventions
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 160
- Registration Number
- NCT06498323
- Locations
- 🇹🇭
Siriraj Stroke Center,Siriraj Hospital, Bangkok, Thailand
ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
- Conditions
- Interventions
- First Posted Date
- 2024-03-20
- Last Posted Date
- 2024-10-01
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 4000
- Registration Number
- NCT06320431
- Locations
- 🇨🇦
University of Alberta, Edmonton, A, Canada
🇨🇦University of British Columbia, Vancouver, British Columbia, Canada
🇨🇦University of Ottawa, Ottawa, Ontario, Canada
Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5
- Conditions
- Interventions
- First Posted Date
- 2024-01-09
- Last Posted Date
- 2024-01-16
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 452
- Registration Number
- NCT06196320
- Locations
- 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China
Tenecteplase Thrombolytic Therapy for Acute Ischemic Stroke in China
- First Posted Date
- 2023-10-12
- Last Posted Date
- 2023-10-12
- Lead Sponsor
- Huashan Hospital
- Target Recruit Count
- 1200
- Registration Number
- NCT06078995
- Locations
- 🇨🇳
Xin Chen, Shanghai, China
Tenecteplase for Acute Ischemic Stroke Within 4.5 to 6 Hours of Onset (EXIT-BT2)
- First Posted Date
- 2023-08-24
- Last Posted Date
- 2024-07-17
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 1440
- Registration Number
- NCT06010628
- Locations
- 🇨🇳
Hui-Sheng Chen, ShenYang, None Selected, China
🇨🇳Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China
Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ）
- First Posted Date
- 2023-02-27
- Last Posted Date
- 2023-02-27
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 1630
- Registration Number
- NCT05745259
- Locations
- 🇨🇳
Xuanwu Hospital Capital Medical University, Beijing, Beijing, China
🇨🇳Xuancheng People's Hospital, Xuancheng, Anhui, China
🇨🇳Beijing Tiantan Hospital, Capital Medical University Beijing, Beijing, Beijing, China
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
- Conditions
- Interventions
- First Posted Date
- 2023-01-27
- Last Posted Date
- 2024-10-01
- Target Recruit Count
- 332
- Registration Number
- NCT05701956
- Locations
- 🇨🇳
The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China
Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation
- Conditions
- Interventions
- First Posted Date
- 2023-01-13
- Last Posted Date
- 2024-04-11
- Target Recruit Count
- 208
- Registration Number
- NCT05684172
- Locations
- 🇨🇳
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei, Anhui, China
Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)
- First Posted Date
- 2022-12-20
- Last Posted Date
- 2024-07-09
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 228
- Registration Number
- NCT05657457
- Locations
- 🇨🇳
General Hospital of Northern Theater Command, ShenYang, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.