Tenecteplase
- Generic Name
- Tenecteplase
- Brand Names
- Metalyse, Tnkase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 191588-94-0
- Unique Ingredient Identifier
- WGD229O42W
- Background
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease doma...
- Indication
用于溶栓治疗。
- Associated Conditions
- Cardiovascular Mortality
- Associated Therapies
- -
A Safety/Efficacy Study of Intra-coronary Tenecteplase During Balloon Angioplasty to Treat Heart Attacks
- Conditions
- Interventions
- First Posted Date
- 2008-01-30
- Last Posted Date
- 2012-09-07
- Lead Sponsor
- C. Michael Gibson, MS, MD
- Target Recruit Count
- 40
- Registration Number
- NCT00604695
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸Atlanta VA Medical Center, Decatur, Georgia, United States
🇺🇸Northeast Georgia Heart Center, PC, Gainesville, Florida, United States
Treatment of Acute Respiratory Distress Syndrome With Tenecteplase: A Dose Escalation Pilot Study
- Conditions
- First Posted Date
- 2007-02-05
- Last Posted Date
- 2024-10-16
- Lead Sponsor
- Wake Forest University Health Sciences
- Registration Number
- NCT00431379
- Locations
- 🇺🇸
Medical Center of Central GA, Macon, Georgia, United States
A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
- Conditions
- Interventions
- First Posted Date
- 2006-11-06
- Last Posted Date
- 2010-08-10
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 100
- Registration Number
- NCT00395876
A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
- Conditions
- Interventions
- First Posted Date
- 2006-11-06
- Last Posted Date
- 2011-04-27
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 251
- Registration Number
- NCT00396318
A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters
- Conditions
- Interventions
- First Posted Date
- 2006-11-06
- Last Posted Date
- 2010-06-03
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 150
- Registration Number
- NCT00396032
A Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis (HD) Catheters
- First Posted Date
- 2006-11-06
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 223
- Registration Number
- NCT00396253
Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)
- Conditions
- Interventions
- First Posted Date
- 2005-11-11
- Last Posted Date
- 2015-03-17
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 112
- Registration Number
- NCT00252239
- Locations
- 🇺🇸
Colorado Neurological Institutes, Englewood, Colorado, United States
🇺🇸University of California at San Diego, San Diego, California, United States
🇺🇸Johns Hopkins-Bayview Medical Center, Baltimore, Maryland, United States
Tenecteplase Pulmonary Embolism Italian Study
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2008-05-06
- Lead Sponsor
- University Of Perugia
- Target Recruit Count
- 180
- Registration Number
- NCT00222651
- Locations
- 🇮🇹
Dipartimento di Cardiologia - Ospedale del Delta, Lagosanto, Ferrara, Italy
🇮🇹Divisione di Cardiologia - Azienda Ospedaliera di Venere -Giovanni XXIII, Bari, Italy
🇮🇹Unità Operativa di Cardiologia - Azienda Ospedaliera - Ospedale Civile di Vimercate, Desio, Milano, Italy
A Trial Evaluating the Efficacy and Safety of Tenecteplase Together With Unfractionated Heparin Prior to Early Percutaneous Coronary Intervention (PCI) as Compared to Standard Primary PCI in Patients With Acute Myocardial Infarction (ASSENT 4 PCI)
- Conditions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2013-10-29
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 1671
- Registration Number
- NCT00168792
- Locations
- 🇹🇷
Boehringer Ingelheim Investigational Site, Izmir, Turkey
Thrombolysis Using Tenecteplase (Metalyse®) in Cardiac Arrest - The TROICA Trial
- Conditions
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2013-10-29
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 1050
- Registration Number
- NCT00157261
- Locations
- 🇦🇹
Univ.-Klinik f. Notfallmedizin, Wien, Austria
🇧🇪AZ VUB, Bruxelles, Belgium
🇧🇪AZ Groeningen, Kortrijk, Belgium
Drug Development Updates
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