Tenecteplase
- Generic Name
- Tenecteplase
- Brand Names
- Metalyse, Tnkase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 191588-94-0
- Unique Ingredient Identifier
- WGD229O42W
- Background
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease doma...
- Indication
用于溶栓治疗。
- Associated Conditions
- Cardiovascular Mortality
- Associated Therapies
- -
Low-Dose Tenecteplase in Covid-19 Diagnosed With Pulmonary Embolism
- Conditions
- Interventions
- First Posted Date
- 2020-09-22
- Last Posted Date
- 2021-10-26
- Lead Sponsor
- Cedars-Sinai Medical Center
- Target Recruit Count
- 2
- Registration Number
- NCT04558125
- Locations
- 🇺🇸
Cedars-Sinai Medical Center, Los Angeles, California, United States
CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase II
- Conditions
- Interventions
- First Posted Date
- 2020-08-18
- Last Posted Date
- 2023-11-29
- Lead Sponsor
- Huashan Hospital
- Target Recruit Count
- 224
- Registration Number
- NCT04516993
- Locations
- 🇨🇳
Huashan Hospital, Shanghai, Shanghai, China
Tenecteplase in Patients With COVID-19
- Conditions
- Interventions
- First Posted Date
- 2020-08-10
- Last Posted Date
- 2023-04-06
- Lead Sponsor
- Hooman Poor
- Target Recruit Count
- 13
- Registration Number
- NCT04505592
- Locations
- 🇺🇸
Mount Sinai Hospital, New York, New York, United States
Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients With Large Vessel Occlusion
- Conditions
- Interventions
- First Posted Date
- 2020-07-02
- Last Posted Date
- 2024-06-26
- Lead Sponsor
- University of Melbourne
- Target Recruit Count
- 740
- Registration Number
- NCT04454788
- Locations
- 🇦🇺
John Hunter Hospital, Newcastle, New South Wales, Australia
🇦🇺Liverpool Hospital, Liverpool, New South Wales, Australia
🇦🇺Royal Adelaide Hospital, Adelaide, South Australia, Australia
Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance
- Conditions
- Interventions
- First Posted Date
- 2019-08-28
- Last Posted Date
- 2021-12-08
- Lead Sponsor
- Melbourne Health
- Target Recruit Count
- 104
- Registration Number
- NCT04071613
- Locations
- 🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia
🇦🇺Alfred Hopsital, Melbourne, Australia
🇦🇺Eastern Health, Melbourne, Victoria, Australia
Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke
- Conditions
- Interventions
- First Posted Date
- 2019-03-26
- Last Posted Date
- 2023-05-12
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 1600
- Registration Number
- NCT03889249
- Locations
- 🇨🇦
St. Michaels Hospital, Toronto, Ontario, Canada
🇨🇦London Health Sciences, London, Ontario, Canada
🇨🇦Hamilton Health Sciences General Hospital, Hamilton, Ontario, Canada
The Norwegian Tenecteplase Stroke Trial 2
- Conditions
- Interventions
- First Posted Date
- 2019-02-26
- Last Posted Date
- 2023-09-15
- Lead Sponsor
- Haukeland University Hospital
- Target Recruit Count
- 201
- Registration Number
- NCT03854500
- Locations
- 🇳🇴
Haukeland University Hospital, Bergen, Norway
Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)
- First Posted Date
- 2017-11-13
- Last Posted Date
- 2020-03-04
- Lead Sponsor
- Neuroscience Trials Australia
- Target Recruit Count
- 300
- Registration Number
- NCT03340493
- Locations
- 🇦🇺
Ballarat Health Services, Ballarat, Victoria, Australia
🇦🇺Austin Hospital, Heidelberg, Victoria, Australia
🇦🇺Albury Hospital, Albury, New South Wales, Australia
Tenecteplase in Wake-up Ischaemic Stroke Trial
- First Posted Date
- 2017-06-08
- Last Posted Date
- 2021-05-14
- Lead Sponsor
- University Hospital of North Norway
- Target Recruit Count
- 600
- Registration Number
- NCT03181360
- Locations
- 🇺🇸
University of Massachusetts Medical School, Worcester, Massachusetts, United States
🇳🇴Sykehuset Levanger, Levanger, Norway
🇳🇴Bærum sykehus Vestre Viken HF, Sandvika, Norway
STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2016-05-19
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- KU Leuven
- Target Recruit Count
- 609
- Registration Number
- NCT02777580
- Locations
- 🇨🇱
Hospital de Tocopilla, Tocopilla, Chile
🇨🇱Hospital Regional de Antofagasta, Antofagasta, Chile
🇷🇸Institute for cardiovascular diseases Dedinje, Cardiovascular research sector, Belgrade, Serbia
Drug Development Updates
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