Tenecteplase
- Generic Name
- Tenecteplase
- Brand Names
- Metalyse, Tnkase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 191588-94-0
- Unique Ingredient Identifier
- WGD229O42W
- Background
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease doma...
- Indication
用于溶栓治疗。
- Associated Conditions
- Cardiovascular Mortality
- Associated Therapies
- -
Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction
- Conditions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2013-10-29
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 270
- Registration Number
- NCT00148460
- Locations
- 🇰🇷
Dongsan Medical Center, Jung-Ku, Korea, Republic of
🇰🇷Chunnam University Hospital, Kwang-Ju, Korea, Republic of
🇨🇳Beijing University, Beijing, China
Which Therapy for Acute Heart Attacks? (The WEST Study)
- Conditions
- First Posted Date
- 2005-07-21
- Last Posted Date
- 2017-05-19
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 300
- Registration Number
- NCT00121446
- Locations
- 🇨🇦
Queen Elizabeth II Hospital, Halifax, Nova Scotia, Canada
🇨🇦Grey Nuns Community Hospital, Edmonton, Alberta, Canada
🇨🇦Misericordia Hospital, Edmonton, Alberta, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.