Propranolol

Generic Name
Propranolol
Brand Names
Hemangeol, Hemangiol, Inderal, Innopran
Drug Type
Small Molecule
Chemical Formula
C16H21NO2
CAS Number
525-66-6
Unique Ingredient Identifier
9Y8NXQ24VQ
Background

Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication

Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions
Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)
Associated Therapies
-
Clinical Trials
Related News

Neoadjuvant Propanolol in Breast Cancer

Phase 2
Terminated
Conditions
Breast Cancer
Interventions
Drug: propanolol
First Posted Date
2015-11-04
Last Posted Date
2018-03-01
Lead Sponsor
Texas Tech University Health Sciences Center, El Paso
Target Recruit Count
2
Registration Number
NCT02596867
Locations
🇺🇸

Texas Tech University HSC, El Paso, Texas, United States

Nadolol Versus Propranolol in Children With Infantile Hemangiomas

Phase 3
Completed
Conditions
Infantile Hemangioma
Interventions
Drug: Nadolol
Drug: Propranolol
First Posted Date
2015-07-22
Last Posted Date
2020-10-28
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
74
Registration Number
NCT02505971
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response

Phase 4
Completed
Conditions
Essential Tremor
Tremor
Interventions
Other: Ethanol
Drug: Propranolol
First Posted Date
2015-07-13
Last Posted Date
2020-12-02
Lead Sponsor
University of California, San Diego
Target Recruit Count
56
Registration Number
NCT02495883
Locations
🇺🇸

University of California, San Diego, La Jolla, California, United States

Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)

Not Applicable
Conditions
Liver Cirrhoses
Interventions
Drug: Propanolol
First Posted Date
2015-06-29
Last Posted Date
2019-01-31
Lead Sponsor
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Target Recruit Count
39
Registration Number
NCT02484573
Locations
🇲🇽

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding

First Posted Date
2015-06-22
Last Posted Date
2021-12-02
Lead Sponsor
West China Hospital
Target Recruit Count
100
Registration Number
NCT02477384
Locations
🇨🇳

West China Hospital, Chengdu, Sichuan, China

Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism

First Posted Date
2015-06-10
Last Posted Date
2019-02-06
Lead Sponsor
Mayo Clinic
Target Recruit Count
165
Registration Number
NCT02467400
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Fenofibrate and Propranolol in Burn Patients

Phase 2
Terminated
Conditions
Burn
Interventions
Drug: Fenofibrate
Drug: Placebo
Drug: Propranolol
First Posted Date
2015-05-22
Last Posted Date
2019-11-29
Lead Sponsor
The University of Texas Medical Branch, Galveston
Target Recruit Count
18
Registration Number
NCT02452255
Locations
🇺🇸

Shriners Hospitals for Children, Galveston, Texas, United States

Combined Effects of Early Behavioral Intervention and Propranolol on ASD

Not Applicable
Completed
Conditions
Autism
Interventions
Drug: Placebo
Drug: Propranolol
First Posted Date
2015-04-28
Last Posted Date
2024-03-04
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
10
Registration Number
NCT02428205
Locations
🇺🇸

Thompson Center for Autism & Neurodevelopmental Disorders, Columbia, Missouri, United States

Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients

Phase 2
Completed
Conditions
Multiple Myeloma
Interventions
Drug: Propranolol
First Posted Date
2015-04-17
Last Posted Date
2021-06-07
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
25
Registration Number
NCT02420223
Locations
🇺🇸

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Trial of Propranolol in Adults and Adolescents With ASD and Predictors of Response

Not Applicable
Withdrawn
Conditions
Autism
Interventions
Drug: Placebo
Drug: Propranolol
First Posted Date
2015-04-10
Last Posted Date
2016-10-04
Lead Sponsor
University of Missouri-Columbia
Registration Number
NCT02414451
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