Propranolol

Generic Name
Propranolol
Brand Names
Hemangeol, Hemangiol, Inderal, Innopran
Drug Type
Small Molecule
Chemical Formula
C16H21NO2
CAS Number
525-66-6
Unique Ingredient Identifier
9Y8NXQ24VQ
Background

Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication

Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions
Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)
Associated Therapies
-
Clinical Trials
Related News

The Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices

First Posted Date
2017-05-31
Last Posted Date
2021-11-23
Lead Sponsor
West China Hospital
Target Recruit Count
74
Registration Number
NCT03171805
Locations
🇨🇳

West china Hospital, Chengdu, China

8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding in Patients With Child A Cirrhosis

First Posted Date
2017-03-29
Last Posted Date
2021-11-23
Lead Sponsor
West China Hospital
Target Recruit Count
72
Registration Number
NCT03094234
Locations
🇨🇳

West china hospital, Chengdu, China

Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity

Phase 2
Recruiting
Conditions
Retinopathy of Prematurity
Interventions
Drug: Placebo
Drug: Propranolol
First Posted Date
2017-03-20
Last Posted Date
2024-12-12
Lead Sponsor
University of Zurich
Target Recruit Count
276
Registration Number
NCT03083431
Locations
🇩🇪

University Hospital Tübingen, Tübingen, Baden-Württemberg, Germany

🇨🇭

University Hospital Zurich, Zürich, Zurich, Switzerland

🇹🇷

Ankara University School of Medicine Children's Hospital, Ankara, Turkey

Adrenergic System in Islet Transplantation

First Posted Date
2017-03-15
Last Posted Date
2023-08-30
Lead Sponsor
University of Pennsylvania
Target Recruit Count
11
Registration Number
NCT03079921
Locations
🇺🇸

University of Pennsylvania - Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States

a Prospective Cohort Study for Propranolol Treatment in Retinopathy of Prematurity

First Posted Date
2017-01-31
Last Posted Date
2017-02-03
Lead Sponsor
Guangdong Women and Children Hospital
Target Recruit Count
100
Registration Number
NCT03038295

Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants

Not Applicable
Conditions
Retinopathy of Prematurity
Interventions
Drug: Propranolol
First Posted Date
2016-11-30
Last Posted Date
2016-12-01
Lead Sponsor
Huiqing Sun
Target Recruit Count
100
Registration Number
NCT02977000
Locations
🇨🇳

Propranolol, Zhengzhou, Henan, China

MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients

Phase 2
Conditions
Melanoma
Interventions
Drug: Placebo
Drug: Propranolol
First Posted Date
2016-11-15
Last Posted Date
2016-11-15
Lead Sponsor
Azienda Sanitaria di Firenze
Target Recruit Count
546
Registration Number
NCT02962947

Beta Blockade in in Traumatic Brain Injury

Phase 4
Completed
Conditions
Brain Injuries, Traumatic
Interventions
Drug: Propranolol
First Posted Date
2016-11-06
Last Posted Date
2020-06-04
Lead Sponsor
University of Tennessee
Target Recruit Count
26
Registration Number
NCT02957331
Locations
🇺🇸

Regional One Health, Memphis, Tennessee, United States

Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol

Phase 4
Conditions
Hyperalgesia
Interventions
Drug: Saline
Drug: Propranolol
First Posted Date
2016-10-17
Last Posted Date
2016-10-27
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
80
Registration Number
NCT02934763

Trial of Propranolol in Children and Youth With Autism Spectrum Disorder and Predictors of Response

First Posted Date
2016-08-18
Last Posted Date
2020-10-08
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
69
Registration Number
NCT02871349
Locations
🇺🇸

Thompson Center for Autism & Neurodevelopmental Disorders, Columbia, Missouri, United States

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