Propranolol

Generic Name: Propranolol

Brand Names: Hemangeol, Hemangiol, Inderal, Innopran

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₁NO_₂

CAS Number: 525-66-6

Unique Ingredient Identifier: 9Y8NXQ24VQ

Background: Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication: Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions: Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)

Associated Therapies: -

Clinical Trials

Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)

Phase 2

Terminated

Conditions: Hemangioma

Interventions: Drug: Prednisolone (Corticosteroid)
Drug: Placebo
Drug: Propranolol

First Posted Date: 2010-02-24

Last Posted Date: 2018-10-04

Lead Sponsor: Seattle Children's Hospital

Target Recruit Count: 9

Registration Number: NCT01074437

Locations: 🇺🇸
Seattle Children's Hospital, Seattle, Washington, United States

Beta Blockers for the Treatment of Asthma

Phase 2

Completed

Conditions: Asthma

Interventions: Drug: placebo
Drug: propranolol

First Posted Date: 2010-02-24

Last Posted Date: 2019-04-12

Lead Sponsor: University of Dundee

Target Recruit Count: 18

Registration Number: NCT01074853

Locations: 🇬🇧
Asthma and Allergy Research Group, Unviersity of Dundee, Dundee, United Kingdom

Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma

Phase 2

Completed

Conditions: Hemangioma

Interventions: Drug: Prednisone
Drug: Propranolol

First Posted Date: 2010-02-19

Last Posted Date: 2014-12-02

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 50

Registration Number: NCT01072045

Locations: 🇧🇷
Instituto de Tratamento do Câncer Infantil (Pediatric Cancer Treatment Institute) - ITACI - ICr-HCFMUSP (Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Sao Paulo, Brazil

Beta Blockers In Acute Ischemic Stroke

Phase 2

Completed

Conditions: Stroke

Interventions: Drug: Propranolol

First Posted Date: 2010-02-03

Last Posted Date: 2015-10-14

Lead Sponsor: Wilhelm Haverkamp

Target Recruit Count: 20

Registration Number: NCT01061190

Locations: 🇩🇪
Charité, University Berlin, Center for Stroke Research Berlin, Berlin, Germany

Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal

Phase 4

Completed

Conditions: Esophageal Varices
Portal Hypertension Gastropathy
Spontaneous Bacterial Peritonitis
Hepatic Encephalopathy
Ascites

Interventions: Drug: placebo
Drug: carvedilol
Drug: propranolol

First Posted Date: 2010-01-29

Last Posted Date: 2017-08-22

Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Target Recruit Count: 201

Registration Number: NCT01059396

Locations: 🇪🇸
Hospital Arnau de Vilanova, Lérida, Spain
🇪🇸
Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
🇪🇸
Hospital German Trias i Pujol, Badalona, Spain

and more 5 locations

Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis

Phase 2

Withdrawn

Conditions: Recurrent Respiratory Papillomatosis

Interventions: Drug: Propranolol

First Posted Date: 2010-01-28

Last Posted Date: 2013-11-21

Lead Sponsor: Massachusetts Eye and Ear Infirmary

Registration Number: NCT01058317

Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy

Phase 2

Completed

Conditions: Infantile Hemangioma

Interventions: Drug: Placebo
Drug: Propranolol

First Posted Date: 2010-01-26

Last Posted Date: 2015-12-10

Lead Sponsor: Pierre Fabre Dermatology

Target Recruit Count: 512

Registration Number: NCT01056341

Locations: 🇺🇸
Cardinal Glennon Children's Hospital, St.Louis, Missouri, United States
🇨🇦
The Hospital for Sick Children, Toronto, Canada
🇫🇷
Hopital Nord-CHU St Etienne, St-Etienne, France

and more 56 locations