Propranolol

Generic Name: Propranolol

Brand Names: Hemangeol, Hemangiol, Inderal, Innopran

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₁NO_₂

CAS Number: 525-66-6

Unique Ingredient Identifier: 9Y8NXQ24VQ

Background: Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication: Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions: Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)

Associated Therapies: -

Clinical Trials

Beta-blockers for Prevention Of Growth Of Small Esophageal Varices In Cirrhosis: An Randomized Controlled Trial (RCT)

Not Applicable

Completed

Conditions: Cirrhosis

Interventions: Drug: Placebo
Drug: Propranolol

First Posted Date: 2008-10-15

Last Posted Date: 2009-12-21

Lead Sponsor: Govind Ballabh Pant Hospital

Target Recruit Count: 164

Registration Number: NCT00772057

Locations: 🇮🇳
Department of Gastroenterology, G B Pant Hospital, New Delhi, Delhi, India

A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol

Phase 4

Completed

Conditions: Posttraumatic Stress Disorder

Interventions: Drug: Propranolol
Drug: Placebo

First Posted Date: 2008-07-03

Last Posted Date: 2017-04-10

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 23

Registration Number: NCT00709735

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
VA Medical Center, Manchester, New Hampshire, United States

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Phase 1

Terminated

Conditions: Cocaine Dependence

Interventions: Drug: Propranolol
Drug: Placebo

First Posted Date: 2008-06-03

Last Posted Date: 2019-12-17

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 40

Registration Number: NCT00688805

Locations: 🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States

A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers

Phase 1

Completed

Conditions: Pulmonary Disease, Chronic Obstructive

Interventions: Drug: GSK961081
Drug: GSK961081 matching placebo
Drug: Propranolol
Drug: Propranolol matching placebo

First Posted Date: 2008-06-02

Last Posted Date: 2021-10-06

Lead Sponsor: Theravance Biopharma

Target Recruit Count: 23

Registration Number: NCT00687700

Locations: 🇬🇧
GSK Investigational Site, Harrow, Middlesex, United Kingdom

Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation

Phase 2

Terminated

Conditions: Burns

Interventions: Procedure: Stable Isotope Infusion Study
Procedure: Collection of blood and tissues
Drug: Humatrope
Drug: Ketoconazole
Drug: Oxandrolone and propranolol combined
Drug: Placebo
Drug: Humatrope and propranolol combined
Behavioral: Exercise--Hospital supervised intensive exercise program
Behavioral: Home exercise program
Drug: Oxandrolone
Drug: Propranolol

First Posted Date: 2008-05-12

Last Posted Date: 2019-11-29

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 1126

Registration Number: NCT00675714

Locations: 🇺🇸
University of Texas Medical Branch, Galveston, Texas, United States

Assessment of Mechanisms of Improved Wound Healing

Phase 2

Completed

Conditions: Burns

Interventions: Procedure: Stable Isotope Infusion study
Drug: IGF-1/IGFBP-3
Drug: Insulin High Dose
Drug: Itraconazole
Drug: Propranolol
Drug: Insulin Low Dose
Drug: Growth Hormone and Propranolol
Drug: Growth Hormone
Drug: Placebo or Control
Drug: Oxandrolone and Propranolol
Drug: oxandrolone

First Posted Date: 2008-05-07

Last Posted Date: 2023-07-03

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 644

Registration Number: NCT00673309

Locations: 🇺🇸
University of Texas Medical Branch, Galveston, Texas, United States

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Not Applicable

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: Propranolol
Drug: Amiodarone
Drug: Amiodarone + Propranolol

First Posted Date: 2008-04-07

Last Posted Date: 2008-04-07

Lead Sponsor: Shiraz University of Medical Sciences

Target Recruit Count: 240

Registration Number: NCT00654290

Locations: 🇮🇷
Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital, Shiraz, Fars, Iran, Islamic Republic of