Propranolol
- Generic Name
- Propranolol
- Brand Names
- Hemangeol, Hemangiol, Inderal, Innopran
- Drug Type
- Small Molecule
- Chemical Formula
- C16H21NO2
- CAS Number
- 525-66-6
- Unique Ingredient Identifier
- 9Y8NXQ24VQ
- Background
Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.
Propranolol was granted FDA approval on 13 November 1967.
- Indication
Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.
- Associated Conditions
- Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)
- Associated Therapies
- -
A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline
- Conditions
- Interventions
- First Posted Date
- 2022-01-13
- Last Posted Date
- 2024-01-23
- Target Recruit Count
- 34
- Registration Number
- NCT05189977
- Locations
- 🇺🇸
For additional information regarding sites (California, Texas, New Jersey, Minnesota), Princeton, New Jersey, United States
Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma
- Conditions
- Interventions
- First Posted Date
- 2021-07-29
- Last Posted Date
- 2021-07-29
- Lead Sponsor
- Douglas Mental Health University Institute
- Target Recruit Count
- 150
- Registration Number
- NCT04982211
- Locations
- 🇨🇦
Douglas Mental Health University Institute, Montréal, Quebec, Canada
Impact of Post-Traumatic Stress Disorder Treatment by Reconsolidation Therapy on Fibromyalgia Syndrome
- Conditions
- Interventions
- First Posted Date
- 2021-07-06
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- Centre Hospitalier Henri Laborit
- Target Recruit Count
- 25
- Registration Number
- NCT04950426
- Locations
- 🇫🇷
Centre Hospitalier Henri Laborit, Poitiers, France
🇫🇷Centre Hospitalier Nord-Deux-Sèvres, Thouars, France
Efficacy of Traumatic Memory Modification Using Memory Reconsolidation and Propranolol Among Adolescents With PTSD
- Conditions
- Interventions
- First Posted Date
- 2021-06-10
- Last Posted Date
- 2022-12-01
- Lead Sponsor
- Rennes University Hospital
- Target Recruit Count
- 74
- Registration Number
- NCT04921982
- Locations
- 🇫🇷
AP-HP Louis Mourier, Colombes, France
🇫🇷CHU Poitiers, Poitiers, France
🇫🇷CHU Rouen, Rouen, France
Shortening Duration of Antiarrhythmic Medication for SVT in Infants
- Conditions
- First Posted Date
- 2021-04-08
- Last Posted Date
- 2021-09-29
- Lead Sponsor
- Tampere University Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT04837261
- Locations
- 🇫🇮
Hämeenlinna Central Hospital, Hämeenlinna, Kanta-Häme, Finland
🇫🇮Sakunta Central Hospital, Pori, Satakunta, Finland
🇫🇮Central Finland Central Hospital, Jyväskylä, Central Finland, Finland
Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury
- First Posted Date
- 2021-04-06
- Last Posted Date
- 2021-04-06
- Lead Sponsor
- Minia University
- Target Recruit Count
- 90
- Registration Number
- NCT04833218
- Locations
- 🇪🇬
Faculty Of Medicine, Minya, Egypt
Propranolol for Protracted Labor
- First Posted Date
- 2021-02-05
- Last Posted Date
- 2022-07-28
- Lead Sponsor
- Christiana Care Health Services
- Target Recruit Count
- 80
- Registration Number
- NCT04741698
- Locations
- 🇺🇸
Christiana Care, Newark, Delaware, United States
Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor
- First Posted Date
- 2021-01-05
- Last Posted Date
- 2023-04-13
- Lead Sponsor
- University Medical Centre Ljubljana
- Target Recruit Count
- 61
- Registration Number
- NCT04692844
- Locations
- 🇸🇮
Departmet of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Propranolol With Standard Chemoradiation for Esophageal Adenocarcinoma
- First Posted Date
- 2020-12-23
- Last Posted Date
- 2024-04-05
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 106
- Registration Number
- NCT04682158
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
A Study of Continuous Heart Rate Monitoring in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2020-12-23
- Last Posted Date
- 2021-04-19
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 21
- Registration Number
- NCT04682184
- Locations
- 🇸🇬
Lilly Centre for Clinical Pharmacology, Singapore, Singapore
Drug Development Updates
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