Sodium nitroprusside

Generic Name: Sodium nitroprusside

Brand Names: Nipride, Nipride RTU, Nitropress

Drug Type: Small Molecule

Chemical Formula: C_₅FeN_₆O

CAS Number: 15078-28-1

Unique Ingredient Identifier: 169D1260KM

Background: Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.

Indication: For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure

Associated Conditions: Acute Heart Failure (AHF), Hypertensive crisis, Intraoperative Blood Loss

Associated Therapies: -

Clinical Trials

Early Neurovascular Adaptations in Aging Women

Early Phase 1

Recruiting

Conditions: Aging
Women
Blood Flow
Sympathetic Nervous System

Interventions: Drug: Norepinephrine
Drug: Isoproterenol
Drug: Acetylcholine
Drug: Nitroprusside
Drug: Estrogen

First Posted Date: 2024-07-25

Last Posted Date: 2024-10-01

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 64

Registration Number: NCT06520982

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

Ketamine and Nitroprusside for Depression

Phase 2

Completed

Conditions: Depression

Interventions: Drug: Placebos
Drug: Ketamine
Drug: Nitroprusside

First Posted Date: 2017-04-06

Last Posted Date: 2020-07-02

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 40

Registration Number: NCT03102736

Locations: 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

Vascular Function and Uterine Fibroids

Completed

Conditions: Leiomyoma

Interventions: Device: Brachial artery catheter
Drug: Acetylcholine
Drug: Nitroprusside
Drug: Norepinephrine
Drug: Nitroprusside and phenylephrine

First Posted Date: 2014-04-25

Last Posted Date: 2018-03-02

Lead Sponsor: Mayo Clinic

Target Recruit Count: 28

Registration Number: NCT02123069

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Remifentanil and Nitroprusside for Controlled Hypotension

Not Applicable

Completed

Conditions: Hypotension, Controlled

Interventions: Drug: nitroprusside
Drug: remifentanil

First Posted Date: 2013-12-04

Last Posted Date: 2013-12-04

Lead Sponsor: Jeju National University School of Medicine

Target Recruit Count: 30

Registration Number: NCT02001298

Locations: 🇰🇷
Jeju National University Hospital, Jeju-si, Jeju Special Self-Governing Province, Korea, Republic of

Bevacizumab and Endothelium Dependent Vasodilation

Not Applicable

Completed

Conditions: Hypertension
Cancer
Endothelial Dysfunction

Interventions: Drug: Acetylcholine
Drug: Nitroprusside
Drug: Bevacizumab

First Posted Date: 2010-05-19

Last Posted Date: 2013-01-10

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 24

Registration Number: NCT01125943

Locations: 🇳🇱
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)

Phase 2

Completed

Conditions: Hypertension

Interventions: Drug: placebo infusion
Drug: nitroprusside

First Posted Date: 2008-02-22

Last Posted Date: 2011-12-06

Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Target Recruit Count: 45

Registration Number: NCT00621816

Locations: 🇺🇸
Arkansas Children's Hospital, Little Rock, Arkansas, United States
🇺🇸
Stanford University School of Medicine, Stanford, California, United States
🇺🇸
Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky, United States

and more 4 locations

THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction

Phase 2

Completed

Conditions: Myocardial Infarction

Interventions: Drug: placebo
Drug: nitroprusside
Drug: adenosine

First Posted Date: 2008-01-10

Last Posted Date: 2012-03-27

Lead Sponsor: Catholic University of the Sacred Heart

Target Recruit Count: 240

Registration Number: NCT00590070

Locations: 🇮🇹
Dipartimento Medicina Cardiovascolare, Rome, Italy

Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study

Phase 2

Completed

Conditions: Cerebral Oxygenation

Interventions: Drug: nitroglycerine
Drug: nitroprusside
Drug: sevoflurane

First Posted Date: 2007-09-26

Last Posted Date: 2012-07-13

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 30

Registration Number: NCT00535808

Locations: 🇧🇪
University Hospital Ghent, Ghent, Belgium

Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage

Not Applicable

Completed

Conditions: CVA (Cerebrovascular Accident)
Cerebral Hemorrhage
Intracranial Hemorrhages

First Posted Date: 2005-09-26

Last Posted Date: 2008-06-26

Lead Sponsor: The George Institute

Target Recruit Count: 404

Registration Number: NCT00226096

Locations: 🇦🇺
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
🇦🇺
Royal Adelaide Hospital, Adelaide, South Australia, Australia
🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia

and more 16 locations

Dose-response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room

Phase 2

Completed

Conditions: Hypotension

Interventions: Drug: Nitroprusside

First Posted Date: 2005-08-26

Last Posted Date: 2024-01-02

Lead Sponsor: The Emmes Company, LLC

Target Recruit Count: 211

Registration Number: NCT00135668

Locations: 🇺🇸
Stanford University, Stanford, California, United States

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