Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy
- First Posted Date
- 2014-07-28
- Last Posted Date
- 2023-05-03
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 63
- Registration Number
- NCT02201251
Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults
- Conditions
- Interventions
- First Posted Date
- 2014-07-16
- Last Posted Date
- 2018-06-07
- Lead Sponsor
- Allergan
- Target Recruit Count
- 282
- Registration Number
- NCT02191579
- Locations
- 🇺🇸
Kansas City Bone and Joint Clinic, Overland Park, Kansas, United States
🇺🇸Newport Beach Clinical Research Associates, Inc., Newport Beach, California, United States
🇺🇸California Headache and Balance Center, Fresno, California, United States
Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine
- Conditions
- Interventions
- First Posted Date
- 2014-06-23
- Last Posted Date
- 2021-04-23
- Lead Sponsor
- St. Louis University
- Target Recruit Count
- 35
- Registration Number
- NCT02169830
- Locations
- 🇺🇸
Saint Louis University, Saint Louis, Missouri, United States
Topiramate Trial for Compulsive Buying
- Conditions
- Interventions
- First Posted Date
- 2014-05-14
- Last Posted Date
- 2017-05-09
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 42
- Registration Number
- NCT02138058
- Locations
- 🇧🇷
Associação Viver Bem, São Paulo, SP, Brazil
Topiramate's Effects on Heavy Drinking
- First Posted Date
- 2014-02-28
- Last Posted Date
- 2018-09-21
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 1
- Registration Number
- NCT02074904
- Locations
- 🇺🇸
University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania, United States
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
- Conditions
- Interventions
- First Posted Date
- 2013-09-25
- Last Posted Date
- 2024-10-16
- Target Recruit Count
- 47
- Registration Number
- NCT01950520
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Topiramate in Adolescents With Severe Obesity
- Conditions
- Interventions
- First Posted Date
- 2013-05-21
- Last Posted Date
- 2017-07-02
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 34
- Registration Number
- NCT01859013
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
- Conditions
- Interventions
- First Posted Date
- 2013-03-15
- Last Posted Date
- 2019-04-24
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 169
- Registration Number
- NCT01811940
- Locations
- 🇺🇸
STARS, New York, New York, United States
🇺🇸University of Pennsylvania, Philadelphia, Pennsylvania, United States
Continuous Treatment Study of Topiramate in Migraine Participants
- First Posted Date
- 2013-02-27
- Last Posted Date
- 2013-05-31
- Lead Sponsor
- Janssen Pharmaceutical K.K.
- Target Recruit Count
- 296
- Registration Number
- NCT01799590
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
- Conditions
- Interventions
- First Posted Date
- 2013-02-11
- Last Posted Date
- 2019-04-16
- Lead Sponsor
- Rush University Medical Center
- Target Recruit Count
- 42
- Registration Number
- NCT01789047
- Locations
- 🇺🇸
University of South Florida, Tampa, Florida, United States
🇺🇸Duke University, Durham, North Carolina, United States
🇺🇸Oregon Health Sciences University, Portland, Oregon, United States
Drug Development Updates
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