Topiramate
- Generic Name
- Topiramate
- Brand Names
- Eprontia, Qsymia, Qudexy, Topamax, Trokendi
- Drug Type
- Small Molecule
- Chemical Formula
- C12H21NO8S
- CAS Number
- 97240-79-4
- Unique Ingredient Identifier
- 0H73WJJ391
- Background
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
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- Indication
Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...
- Associated Conditions
- Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight
- Associated Therapies
- Chronic Weight Management therapy, Weight Reduction
Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy
- Conditions
- Interventions
- First Posted Date
- 2013-01-10
- Last Posted Date
- 2024-06-11
- Lead Sponsor
- Kristin R Hoffman
- Target Recruit Count
- 34
- Registration Number
- NCT01765218
- Locations
- 🇺🇸
UC Davis Medical Center, Sacramento, California, United States
Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers
- Conditions
- Interventions
- First Posted Date
- 2013-01-09
- Last Posted Date
- 2016-03-15
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 4
- Registration Number
- NCT01764685
- Locations
- 🇺🇸
University of Pennsylvania Treatment Research Center, Philadelphia, Pennsylvania, United States
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
- Conditions
- Interventions
- First Posted Date
- 2012-12-17
- Last Posted Date
- 2020-10-14
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 32
- Registration Number
- NCT01750268
- Locations
- 🇺🇸
San Francisco VA Medical Center, San Francisco, California, United States
A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
- Conditions
- Interventions
- First Posted Date
- 2012-12-13
- Last Posted Date
- 2021-06-21
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 151
- Registration Number
- NCT01749215
- Locations
- 🇺🇸
San Francisco VA Medical Center, San Francisco, California, United States
A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency
- Conditions
- Interventions
- First Posted Date
- 2012-10-04
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Cady, Roger, M.D.
- Target Recruit Count
- 20
- Registration Number
- NCT01700387
- Locations
- 🇺🇸
Clinvest/A Division of Banyan Group, Inc., Springfield, Missouri, United States
A Study to Assess Tolerability and Efficacy of Topiramate Monotherapy in Recently Diagnosed Patients With Epilepsy
- First Posted Date
- 2012-09-21
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 139
- Registration Number
- NCT01689649
An Observational Study to Evaluate Long-term Retention Rate of Topiramate in Participants With Epilepsy
- First Posted Date
- 2012-09-11
- Last Posted Date
- 2013-09-06
- Lead Sponsor
- Janssen Korea, Ltd., Korea
- Target Recruit Count
- 1234
- Registration Number
- NCT01682681
Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms
- First Posted Date
- 2012-07-16
- Last Posted Date
- 2020-10-20
- Lead Sponsor
- Brown University
- Target Recruit Count
- 82
- Registration Number
- NCT01641445
- Locations
- 🇺🇸
Brown University, Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States
The Childhood and Adolescent Migraine Prevention Study
- Conditions
- Interventions
- First Posted Date
- 2012-04-20
- Last Posted Date
- 2017-08-10
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 488
- Registration Number
- NCT01581281
- Locations
- 🇺🇸
University of Maryland School of Medicine, Baltimore, Maryland, United States
🇺🇸University of Nevada, Reno, Nevada, United States
🇺🇸Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Preventing Brain Injury in Infants With Congenital Heart Disease
- Conditions
- Interventions
- First Posted Date
- 2011-08-31
- Last Posted Date
- 2019-02-08
- Lead Sponsor
- University of California, Davis
- Target Recruit Count
- 24
- Registration Number
- NCT01426542
- Locations
- 🇺🇸
UC Davis Children's Hospital, Sacramento, California, United States
Drug Development Updates
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