Meropenem

Generic Name
Meropenem
Brand Names
Vabomere
Drug Type
Small Molecule
Chemical Formula
C17H25N3O5S
CAS Number
96036-03-2
Unique Ingredient Identifier
YOP6PX0BAO
Background

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.

In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI). Vabomere consists of meropenem and Vaborbactam and is intravenously admininstered. The treatment aims to resolve infection-related symptoms and achieve negative urine culture, where the infections are proven or strongly suspected to be caused by susceptible bacteria.

Indication

For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.

Associated Conditions
Bacterial Infections, Complicated Intra-Abdominal Infections (cIAIs), Meningitis, Bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Complicated skin infection bacterial
Associated Therapies
-

Population Pharmacokinetics of Prolonged Infusion Meropenem in Cystic Fibrosis (CF) Children

First Posted Date
2011-09-07
Last Posted Date
2018-03-20
Lead Sponsor
Joseph Kuti
Target Recruit Count
30
Registration Number
NCT01429259
Locations
🇺🇸

St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, United States

🇺🇸

Connecticut Children's Medical Center, Hartford, Connecticut, United States

🇺🇸

Nationwide Children's Hospital, Columbus, Ohio, United States

and more 4 locations

GSK2251052 in the Treatment of Complicated Intra-abdominal Infections

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2011-06-27
Last Posted Date
2017-11-29
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
15
Registration Number
NCT01381562
Locations
🇪🇸

GSK Investigational Site, Pama de Mallorca, Spain

Trial of Colistin Versus Meropenem in Ventilator-associated Pneumonia (VAP) (CR-GNB)

First Posted Date
2011-02-09
Last Posted Date
2016-02-03
Lead Sponsor
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Target Recruit Count
232
Registration Number
NCT01292031
Locations
🇬🇷

Sotiria Hospital, Medical School University of Athens, Athens, Greece

🇬🇷

General Hospital of Larissa, Thessalia University, Athens, Greece

🇮🇹

AO Ospedale Niguarda Ca Granda Milano, Milan, Italy

and more 30 locations

Duration of Antibiotics in Infective Exacerbations of Cystic Fibrosis

First Posted Date
2010-01-08
Last Posted Date
2010-04-13
Lead Sponsor
Imperial College London
Target Recruit Count
240
Registration Number
NCT01044719
Locations
🇬🇧

Department of Cystic Fibrosis, Royal Brompton Hospital, London, United Kingdom

Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections

First Posted Date
2008-09-15
Last Posted Date
2018-07-03
Lead Sponsor
Pfizer
Target Recruit Count
204
Registration Number
NCT00752219
Locations
🇺🇸

Cedars-Sinai Medical Center Dept of Surgery, Los Angeles, California, United States

🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

🇺🇸

University of Southern California, Los Angeles, California, United States

and more 42 locations

Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections

First Posted Date
2008-02-22
Last Posted Date
2023-04-25
Lead Sponsor
The Emmes Company, LLC
Target Recruit Count
200
Registration Number
NCT00621192
Locations
🇺🇸

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

🇺🇸

Magee Women's Hospital, Pittsburgh, Pennsylvania, United States

🇺🇸

University of Texas Southwestern Medical Center, Dallas, Texas, United States

and more 23 locations

Complicated Skin and Skin Structure Infections

First Posted Date
2008-02-21
Last Posted Date
2017-09-01
Lead Sponsor
Pfizer
Target Recruit Count
1000
Registration Number
NCT00619710

A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis

Not Applicable
Conditions
Interventions
First Posted Date
2007-12-24
Last Posted Date
2008-06-04
Lead Sponsor
University of Oxford
Target Recruit Count
750
Registration Number
NCT00579956
Locations
🇹🇭

Sappasithiprasong Hospital, Ubonratchathani, Ubon, Thailand

🇹🇭

Udon Thani General Hospital, Udon Thani, Thailand

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