Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Decision-Making in Bipolar Disorder
- Conditions
- Interventions
- First Posted Date
- 2011-11-01
- Last Posted Date
- 2017-05-31
- Lead Sponsor
- Emory University
- Target Recruit Count
- 37
- Registration Number
- NCT01463111
- Locations
- 🇺🇸
Emory University Mood and Anxiety Disorders Program, Atlanta, Georgia, United States
Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa
- Conditions
- Interventions
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2016-04-14
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT01399515
- Locations
- 🇰🇷
Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea, Republic of
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
- First Posted Date
- 2011-04-27
- Last Posted Date
- 2016-06-09
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 62
- Registration Number
- NCT01342549
- Locations
- 🇺🇸
Iowa City VA Health Care System, Iowa City, IA, Iowa City, Iowa, United States
🇺🇸Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas, United States
Valproic Acid With Chemoradiotherapy for Pancreatic Cancer
- First Posted Date
- 2011-04-12
- Last Posted Date
- 2011-04-12
- Lead Sponsor
- Soroka University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT01333631
Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures
- Conditions
- Interventions
- First Posted Date
- 2010-12-31
- Last Posted Date
- 2010-12-31
- Lead Sponsor
- Hillel Yaffe Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT01268904
- Locations
- 🇮🇱
Hillel Yaffe Medical Center, Hadera, Israel
Valproate Versus Ketorolac Versus Metoclopramide
- Conditions
- Interventions
- First Posted Date
- 2010-12-29
- Last Posted Date
- 2018-06-04
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 330
- Registration Number
- NCT01267864
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Trial of Oral Valproic Acid for Retinitis Pigmentosa
- First Posted Date
- 2010-11-03
- Last Posted Date
- 2017-12-02
- Lead Sponsor
- Foundation Fighting Blindness
- Target Recruit Count
- 90
- Registration Number
- NCT01233609
- Locations
- 🇺🇸
University of Utah School of Medicine, Moran Eye Center, Salt Lake City, Utah, United States
🇺🇸University of Tennessee, Hamilton Eye Institute, Memphis, Tennessee, United States
🇺🇸Retina Foundation of the Southwest, Dallas, Texas, United States
Temsirolimus and Valproic Acid in Treating Young Patients With Relapsed Neuroblastoma, Bone Sarcoma, or Soft Tissue Sarcoma
- Conditions
- Interventions
- First Posted Date
- 2010-09-17
- Last Posted Date
- 2016-12-23
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 7
- Registration Number
- NCT01204450
- Locations
- 🇺🇸
Carolina Healthcare System, Charlotte, North Carolina, United States
🇺🇸Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States
Valproic Acid With Chemoradiotherapy for Non-Small-Cell Lung Cancer
- First Posted Date
- 2010-09-16
- Last Posted Date
- 2011-03-29
- Lead Sponsor
- Soroka University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT01203735
- Locations
- 🇮🇱
Soroka University Medical Center, Beer Sheva, Israel
Add-on Dextromethorphan in Bipolar Disorders
- Conditions
- Interventions
- First Posted Date
- 2010-08-25
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- National Cheng-Kung University Hospital
- Target Recruit Count
- 300
- Registration Number
- NCT01188265
- Locations
- 🇨🇳
Ru-Band Lu, Tainan, Taiwan
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.